Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe

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Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe. / Fidler, Miranda M.; Reulen, Raoul C.; Winter, David L.; Allodji, Rodrigue S.; Bagnasco, Francesca; Bárdi, Edit; Bautz, Andrea; Bright, Chloe J.; Byrne, Julianne; Feijen, Elizabeth A. M.; Garwicz, Stanislaw; Grabow, Desiree; Gudmundsdottir, Thorgerdur; Guha, Joyeeta; Haddy, Nadia; Jankovic, Momcilo; Kaatsch, Peter; Kaiser, Melanie; Kuonen, Rahel; Linge, Helena; Maule, Milena; Merletti, Franco; Øfstaas, Hilde; Ronckers, Cecile M.; Skinner, Roderick; Teepen, Jop; Terenziani, Monica; Vu-bezin, Giao; Wesenberg, Finn; Wiebe, Thomas; Jakab, Zsuzsanna; Haupt, Riccardo; Lähteenmäki, Päivi; Zaletel, Lorna Zadravec; Kuehni, Claudia E.; Winther, Jeanette F.; De Vathaire, Florent; Kremer, Leontien C.; Hjorth, Lars; Hawkins, Michael M.

In: Journal of the National Cancer Institute, Vol. 110, No. 2, 02.2018.

Research output: Contribution to journalArticle

Harvard

Fidler, MM, Reulen, RC, Winter, DL, Allodji, RS, Bagnasco, F, Bárdi, E, Bautz, A, Bright, CJ, Byrne, J, Feijen, EAM, Garwicz, S, Grabow, D, Gudmundsdottir, T, Guha, J, Haddy, N, Jankovic, M, Kaatsch, P, Kaiser, M, Kuonen, R, Linge, H, Maule, M, Merletti, F, Øfstaas, H, Ronckers, CM, Skinner, R, Teepen, J, Terenziani, M, Vu-bezin, G, Wesenberg, F, Wiebe, T, Jakab, Z, Haupt, R, Lähteenmäki, P, Zaletel, LZ, Kuehni, CE, Winther, JF, De Vathaire, F, Kremer, LC, Hjorth, L & Hawkins, MM 2018, 'Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe', Journal of the National Cancer Institute, vol. 110, no. 2. https://doi.org/10.1093/jnci/djx165

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Fidler, Miranda M. ; Reulen, Raoul C. ; Winter, David L. ; Allodji, Rodrigue S. ; Bagnasco, Francesca ; Bárdi, Edit ; Bautz, Andrea ; Bright, Chloe J. ; Byrne, Julianne ; Feijen, Elizabeth A. M. ; Garwicz, Stanislaw ; Grabow, Desiree ; Gudmundsdottir, Thorgerdur ; Guha, Joyeeta ; Haddy, Nadia ; Jankovic, Momcilo ; Kaatsch, Peter ; Kaiser, Melanie ; Kuonen, Rahel ; Linge, Helena ; Maule, Milena ; Merletti, Franco ; Øfstaas, Hilde ; Ronckers, Cecile M. ; Skinner, Roderick ; Teepen, Jop ; Terenziani, Monica ; Vu-bezin, Giao ; Wesenberg, Finn ; Wiebe, Thomas ; Jakab, Zsuzsanna ; Haupt, Riccardo ; Lähteenmäki, Päivi ; Zaletel, Lorna Zadravec ; Kuehni, Claudia E. ; Winther, Jeanette F. ; De Vathaire, Florent ; Kremer, Leontien C. ; Hjorth, Lars ; Hawkins, Michael M. / Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe. In: Journal of the National Cancer Institute. 2018 ; Vol. 110, No. 2.

Bibtex

@article{5492acfc40cc4b3b806d29718a7f8428,
title = "Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe",
abstract = "Introduction We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors. Methods This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standardized incidence ratios, absolute excess risks, and multivariable-adjusted relative risks and relative excess risks were calculated. All statistical tests were two-sided. Results Overall, survivors were 21.65 times (95{\%} confidence interval = 18.97 to 24.60 times) more likely to be diagnosed with a subsequent primary bone cancer than expected from the general population. The greatest excess numbers of bone cancers were observed after retinoblastoma, bone sarcoma, and soft tissue sarcoma. The excess number of bone cancers declined linearly with both years since diagnosis and attained age (all P < .05). Beyond 40 years from diagnosis and age 40 years, there were at most 0.45 excess bone cancers among all survivors per 10 000 person-years at risk; beyond 30 years from diagnosis and age 30 years, there were at most 5.02 excess bone cancers after each of retinoblastoma, bone sarcoma, and soft tissue sarcoma, per 10 000 person-years at risk. Conclusions For all survivors combined and the cancer groups with the greatest excess number of bone cancers, the excess numbers observed declined with both age and years from diagnosis. These results provide novel, reliable, and unbiased information about risks and risk factors among long-term survivors of childhood and adolescent cancer.",
author = "Fidler, {Miranda M.} and Reulen, {Raoul C.} and Winter, {David L.} and Allodji, {Rodrigue S.} and Francesca Bagnasco and Edit B{\'a}rdi and Andrea Bautz and Bright, {Chloe J.} and Julianne Byrne and Feijen, {Elizabeth A. M.} and Stanislaw Garwicz and Desiree Grabow and Thorgerdur Gudmundsdottir and Joyeeta Guha and Nadia Haddy and Momcilo Jankovic and Peter Kaatsch and Melanie Kaiser and Rahel Kuonen and Helena Linge and Milena Maule and Franco Merletti and Hilde {\O}fstaas and Ronckers, {Cecile M.} and Roderick Skinner and Jop Teepen and Monica Terenziani and Giao Vu-bezin and Finn Wesenberg and Thomas Wiebe and Zsuzsanna Jakab and Riccardo Haupt and P{\"a}ivi L{\"a}hteenm{\"a}ki and Zaletel, {Lorna Zadravec} and Kuehni, {Claudia E.} and Winther, {Jeanette F.} and {De Vathaire}, Florent and Kremer, {Leontien C.} and Lars Hjorth and Hawkins, {Michael M.}",
year = "2018",
month = "2",
doi = "10.1093/jnci/djx165",
language = "English",
volume = "110",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe

AU - Fidler, Miranda M.

AU - Reulen, Raoul C.

AU - Winter, David L.

AU - Allodji, Rodrigue S.

AU - Bagnasco, Francesca

AU - Bárdi, Edit

AU - Bautz, Andrea

AU - Bright, Chloe J.

AU - Byrne, Julianne

AU - Feijen, Elizabeth A. M.

AU - Garwicz, Stanislaw

AU - Grabow, Desiree

AU - Gudmundsdottir, Thorgerdur

AU - Guha, Joyeeta

AU - Haddy, Nadia

AU - Jankovic, Momcilo

AU - Kaatsch, Peter

AU - Kaiser, Melanie

AU - Kuonen, Rahel

AU - Linge, Helena

AU - Maule, Milena

AU - Merletti, Franco

AU - Øfstaas, Hilde

AU - Ronckers, Cecile M.

AU - Skinner, Roderick

AU - Teepen, Jop

AU - Terenziani, Monica

AU - Vu-bezin, Giao

AU - Wesenberg, Finn

AU - Wiebe, Thomas

AU - Jakab, Zsuzsanna

AU - Haupt, Riccardo

AU - Lähteenmäki, Päivi

AU - Zaletel, Lorna Zadravec

AU - Kuehni, Claudia E.

AU - Winther, Jeanette F.

AU - De Vathaire, Florent

AU - Kremer, Leontien C.

AU - Hjorth, Lars

AU - Hawkins, Michael M.

PY - 2018/2

Y1 - 2018/2

N2 - Introduction We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors. Methods This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standardized incidence ratios, absolute excess risks, and multivariable-adjusted relative risks and relative excess risks were calculated. All statistical tests were two-sided. Results Overall, survivors were 21.65 times (95% confidence interval = 18.97 to 24.60 times) more likely to be diagnosed with a subsequent primary bone cancer than expected from the general population. The greatest excess numbers of bone cancers were observed after retinoblastoma, bone sarcoma, and soft tissue sarcoma. The excess number of bone cancers declined linearly with both years since diagnosis and attained age (all P < .05). Beyond 40 years from diagnosis and age 40 years, there were at most 0.45 excess bone cancers among all survivors per 10 000 person-years at risk; beyond 30 years from diagnosis and age 30 years, there were at most 5.02 excess bone cancers after each of retinoblastoma, bone sarcoma, and soft tissue sarcoma, per 10 000 person-years at risk. Conclusions For all survivors combined and the cancer groups with the greatest excess number of bone cancers, the excess numbers observed declined with both age and years from diagnosis. These results provide novel, reliable, and unbiased information about risks and risk factors among long-term survivors of childhood and adolescent cancer.

AB - Introduction We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors. Methods This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standardized incidence ratios, absolute excess risks, and multivariable-adjusted relative risks and relative excess risks were calculated. All statistical tests were two-sided. Results Overall, survivors were 21.65 times (95% confidence interval = 18.97 to 24.60 times) more likely to be diagnosed with a subsequent primary bone cancer than expected from the general population. The greatest excess numbers of bone cancers were observed after retinoblastoma, bone sarcoma, and soft tissue sarcoma. The excess number of bone cancers declined linearly with both years since diagnosis and attained age (all P < .05). Beyond 40 years from diagnosis and age 40 years, there were at most 0.45 excess bone cancers among all survivors per 10 000 person-years at risk; beyond 30 years from diagnosis and age 30 years, there were at most 5.02 excess bone cancers after each of retinoblastoma, bone sarcoma, and soft tissue sarcoma, per 10 000 person-years at risk. Conclusions For all survivors combined and the cancer groups with the greatest excess number of bone cancers, the excess numbers observed declined with both age and years from diagnosis. These results provide novel, reliable, and unbiased information about risks and risk factors among long-term survivors of childhood and adolescent cancer.

U2 - 10.1093/jnci/djx165

DO - 10.1093/jnci/djx165

M3 - Article

VL - 110

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 2

ER -