Risk of cardiovascular outcomes among women with endometriosis in the United Kingdom: a retrospective matched cohort study

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Colleges, School and Institutes

Abstract

Objective
To describe the prevalence and incidence of endometriosis and to estimate the risk of cardiovascular outcomes in women with endometriosis.

Design
Population‐based cohort study using The Health Improvement Network database.

Setting
UK primary care

Population
Women aged 16‐50 years were followed through from 1995 to 2018

Methods
Adjusted hazard ratios (aHR) for cardiovascular outcomes comparing women with endometriosis to those without endometriosis were estimated using multivariable Cox regression models. Prevalence and incidence of endometriosis were estimated using annual (1998‐2017) sequential cross‐sectional and cohort studies, respectively.

Main outcome measure
The primary outcome was composite cardiovascular disease (CVD) including, ischaemic heart disease (IHD), heart failure (HF) and cerebrovascular disease. Secondary outcomes were arrhythmia and hypertension.

Results
56090 women with endometriosis and 223669 matched controls without endometriosis were included in the analysis of cardiovascular risk. Compared to women without endometriosis, the aHR for cardiovascular outcomes among women with endometriosis were: composite CVD, 1.24 (95% CI 1.13‐1.37); IHD 1.40 (95% CI 1.22‐1.61 ); cerebrovascular disease, 1.19 (95% CI 1.04‐1.36 ); HF, 0.76 (95% CI 0.54‐1.07 ); arrhythmia, 1.26 (95% CI 1.11‐1.43 ); hypertension, 1.12 (95% CI 1.07‐1.17 ) and all‐cause mortality 0.66 (95% CI 0.59‐0.74) . The incidence of endometriosis was 12.3 per 10000 person‐years in 1998 and 11.5 per 10000 person years in 2017. The prevalence of endometriosis increased from 119.7 per 10000 population in 1998 to 201.28 per 10000 population in 2017.

Conclusion
Endometriosis is associated with an increased risk of cardiovascular outcomes. Young women with endometriosis are a potential target for CVD risk assessment and prevention.

Details

Original languageEnglish
Pages (from-to)1-27
JournalBJOG: An International Journal of Obstetrics & Gynaecology
Volume2021
Issue number00
Early online date8 Mar 2021
Publication statusE-pub ahead of print - 8 Mar 2021

Keywords

  • endometriosis, cardiovascular disaese, stroke, hypertension, arrhythmia