Risk governance of emerging technologies demonstrated in terms of its applicability to nanomaterials

Research output: Contribution to journalReview articlepeer-review


  • Panagiotis Isigonis
  • Antreas Afantitis
  • Dalila Antunes
  • Alena Bartonova
  • Ali Beitollahi
  • Nils Bohmer
  • Evert Bouman
  • Qasim Chaudhry
  • Mihaela Roxana Cimpan
  • Emil Cimpan
  • Shareen Doak
  • Damien Dupin
  • Doreen Fedrigo
  • Valérie Fessard
  • Maciej Gromelski
  • Arno C Gutleb
  • Sabina Halappanavar
  • Peter Hoet
  • Nina Jeliazkova
  • Stéphane Jomini
  • Sabine Lindner
  • Igor Linkov
  • Eleonora Marta Longhin
  • Ineke Malsch
  • Antonio Marcomini
  • Espen Mariussen
  • Jesus M de la Fuente
  • Georgia Melagraki
  • Finbarr Murphy
  • Michael Neaves
  • Rolf Packroff
  • Stefan Pfuhler
  • Tomasz Puzyn
  • Qamar Rahman
  • Elise Rundén Pran
  • Elena Semenzin
  • Tommaso Serchi
  • Christoph Steinbach
  • Benjamin Trump
  • Ivana Vinković Vrček
  • David Warheit
  • Mark R Wiesner
  • Egon Willighagen
  • Maria Dusinska

External organisations

  • Ca'Foscari University of Venice
  • Nanoinformatics Department
  • Rheumatology Department, Hospital de Santa Maria, CHLN, Lisbon Academic Medical Centre, Lisbon, Portugal.
  • Norwegian Institute for Air Research
  • INIC
  • Society for Chemical Engineering and Biotechnology (DECHEMA)
  • University of Chester, Chester, UK; Cheshire and Wirral Partnership NHS Foundation Trust, Chester, UK.
  • Center for Cancer Biomarkers Research, University of Bergen, Bergen, Norway.
  • Western Norway University of Applied Sciences
  • Swansea University Medical School, Institute of Life Science, Swansea University, Swansea, United Kingdom.
  • ECOS - European Environmental Citizens Organization for Standardization
  • ANSES Fougères Laboratory
  • University of Gdańsk
  • Luxembourg Institute of Science and Technology
  • Environmental Health Science and Research Bureau
  • imec-COSIC, KU Leuven, Leuven-Heverlee, Belgium
  • IDEA Ideaconsult Limited Liability Company
  • Brain Imaging Center, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Univ Birmingham Edgbaston
  • Malsch TechnoValuation
  • Instituto de Ciencia de Materiales de Aragón (ICMA)
  • TGO - Transgero Limited
  • BAuA - Federal Institute for Occupational Safety and Health
  • Miami Valley Innovation Center
  • Amity University
  • Institute for Medical Research and Occupational Health
  • Warheit Scientific LLC
  • Center for the Environmental Implications of NanoTechnology (CEINT) Duke University
  • University of Maastricht, Maastricht Medical Center, Maastricht, the Netherlands


Nanotechnologies have reached maturity and market penetration that require nano-specific changes in legislation and harmonization among legislation domains, such as the amendments to REACH for nanomaterials (NMs) which came into force in 2020. Thus, an assessment of the components and regulatory boundaries of NMs risk governance is timely, alongside related methods and tools, as part of the global efforts to optimise nanosafety and integrate it into product design processes, via Safe(r)-by-Design (SbD) concepts. This paper provides an overview of the state-of-the-art regarding risk governance of NMs and lays out the theoretical basis for the development and implementation of an effective, trustworthy and transparent risk governance framework for NMs. The proposed framework enables continuous integration of the evolving state of the science, leverages best practice from contiguous disciplines and facilitates responsive re-thinking of nanosafety governance to meet future needs. To achieve and operationalise such framework, a science-based Risk Governance Council (RGC) for NMs is being developed. The framework will provide a toolkit for independent NMs' risk governance and integrates needs and views of stakeholders. An extension of this framework to relevant advanced materials and emerging technologies is also envisaged, in view of future foundations of risk research in Europe and globally.

Bibliographic note

Funding Information: This study received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 814425 (RiskGONE) and No 814572 (NanoSolveIT). Publisher Copyright: © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Copyright: Copyright 2020 Elsevier B.V., All rights reserved.


Original languageEnglish
Article number2003303
Issue number36
Publication statusPublished - 23 Jul 2020


  • nanomaterials, nanosafety, regulation, risk governance council, risk governance framework