Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Wellcome Trust Case Control Consortium; YEAR consortium; BIRAC Consortium

doi:10.1038/ng.218

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Wellcome Trust Case Control Consortium, YEAR consortium, BIRAC Consortium

Birmingham Medical School

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Original language	English
Pages (from-to)	1156-1159
Number of pages	4
Journal	Nature Genetics
Volume	40
Issue number	10
DOIs	https://doi.org/10.1038/ng.218
Publication status	Published - 1 Oct 2008

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http://www.nature.com/articles/ng.218

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title = "Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13",

abstract = "The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.",

author = "Anne Barton and Wendy Thomson and Xiayi Ke and Steve Eyre and Anne Hinks and John Bowes and Darren Plant and Gibbons, {Laura J} and Wilson, {Anthony G} and {Wellcome Trust Case Control Consortium} and {YEAR consortium} and {BIRAC Consortium} and Bax, {Deborah E} and Morgan, {Ann W.} and Paul Emery and Sophia Steer and Lynne Hocking and Reid, {David M} and Paul Wordsworth and Pille Harrison and Jane Worthington and Jayne Franklyn",

year = "2008",

month = oct,

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doi = "10.1038/ng.218",

language = "English",

volume = "40",

pages = "1156--1159",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

AU - Barton, Anne

AU - Thomson, Wendy

AU - Ke, Xiayi

AU - Eyre, Steve

AU - Hinks, Anne

AU - Bowes, John

AU - Plant, Darren

AU - Gibbons, Laura J

AU - Wilson, Anthony G

AU - Wellcome Trust Case Control Consortium

AU - YEAR consortium

AU - BIRAC Consortium

AU - Bax, Deborah E

AU - Morgan, Ann W.

AU - Emery, Paul

AU - Steer, Sophia

AU - Hocking, Lynne

AU - Reid, David M

AU - Wordsworth, Paul

AU - Harrison, Pille

AU - Worthington, Jane

AU - Franklyn, Jayne

PY - 2008/10/1

Y1 - 2008/10/1

N2 - The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

AB - The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

U2 - 10.1038/ng.218

DO - 10.1038/ng.218

M3 - Article

C2 - 18794857

SN - 1546-1718

VL - 40

SP - 1156

EP - 1159

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Abstract

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