Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Research output: Contribution to journalArticlepeer-review

Authors

  • Wellcome Trust Case Control Consortium
  • YEAR consortium
  • BIRAC Consortium

Colleges, School and Institutes

Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Details

Original languageEnglish
Pages (from-to)1156-1159
Number of pages4
JournalNature Genetics
Volume40
Issue number10
Publication statusPublished - 1 Oct 2008