Rheumatoid arthritis: The two faces of Rsk2 in hyperplastic disease

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

Given the established role of 90 kDa ribosomal S6 kinases (Rsk) in oncogenesis, and the promise of new Rsk-blocking cancer treatments, it is perhaps surprising that Rsk2-mediated inhibition of hyperplasia has now been demonstrated to occur in the arthritic synovium. Does this functional duality make Rsk2 a risky target for the treatment of rheumatoid arthritis?

Details

Original languageEnglish
Pages (from-to)203-205
Number of pages3
JournalNature Reviews Rheumatology
Volume11
Issue number4
Early online date27 Jan 2015
Publication statusPublished - Apr 2015