Reward and punishment enhance motor adaptation in stroke

Research output: Contribution to journalArticle

Authors

  • Graziella Quattrocchi
  • Richard Greenwood
  • John C. Rothwell
  • Joseph Galea
  • Sven Bestmann

External organisations

  • Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London
  • National Hospital for Neurology and Neurosurgery, UCLH NHS Trust

Abstract

The effects of motor learning, such as motor adaptation, in stroke rehabilitation are often transient, thus mandating approaches that enhance the amount of learning and retention. Previously, we showed in young individuals that reward- and punishment-feedback have dissociable effects on motor adaptation, with punishment improving adaptation and reward enhancing retention. If these findings were able to generalise to stroke patients, they would provide a way to optimize motor learning in these patients. Therefore, we tested this in 45 chronic stroke patients allocated in three groups. Patients performed reaching movements with their paretic arm with a robotic manipulandum. After training (day 1), day 2 involved adapting to a novel force-field. During this adaptation phase, patients received performance-based feedback according to the group they were allocated: reward, punishment or no feedback (neutral). On day 3, patients readapted to the force-field but all groups now received neutral feedback. All patients adapted, with reward and punishment groups displaying greater adaptation and readaptation than the neutral group, irrespective of demographic, cognitive or functional differences. Remarkably, the reward and punishment groups adapted to similar degree as healthy controls. Finally, the reward group showed greater retention. This study provides, for the first time, evidence that reward and punishment can enhance motor adaptation in stroke patients. Further research on reinforcement-based motor learning regimes is warranted to translate these promising results into clinical practice and improve motor rehabilitation outcomes in stroke patients.

Details

Original languageEnglish
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume88
Issue number9
Early online date4 Apr 2017
Publication statusE-pub ahead of print - 4 Apr 2017

Keywords

  • Adaptation, Motivation, Motor Learning, Reaching, Stroke