Review article: ageing and the neutrophil: no appetite for killing?

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

In the armoury of the immune system developed to combat the various micro-organisms that could invade the host, the neutrophil forms the first line of defence against rapidly dividing bacteria and fungi. However, as humans age they become more susceptible to infection with these microbes and this has been ascribed to a decline in immune status, termed immune senescence. Here we summarize the literature specifically concerning the attenuation of neutrophil function with age and the possible mechanisms underlying their reduced response to infectious agents.

Details

Original languageEnglish
Pages (from-to)411-6
Number of pages6
JournalImmunology
Volume100
Publication statusPublished - 1 Aug 2000