Reusable, robust, and accurate laser-generated photonic nanosensor
Research output: Contribution to journal › Article › peer-review
- Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
- Universidade Estadual de Campinas
- University of Queensland
- University of Cambridge
- Core Biochemical Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust
- Department of Pediatrics, Division of Nephrology, Eastern Virginia Medical School
- National Institute of Science and Technology of Bioanalytics, Institute of Chemistry, University of Campinas
- Australian Institute for Bioengineering and Nanotechnology, University of Queensland
Developing noninvasive and accurate diagnostics that are easily manufactured, robust, and reusable will provide monitoring of high-risk individuals in any clinical or point-of-care environment. We have developed a clinically relevant optical glucose nanosensor that can be reused at least 400 times without a compromise in accuracy. The use of a single 6 ns laser (λ = 532 nm, 200 mJ) pulse rapidly produced off-axis Bragg diffraction gratings consisting of ordered silver nanoparticles embedded within a phenylboronic acid-functionalized hydrogel. This sensor exhibited reversible large wavelength shifts and diffracted the spectrum of narrow-band light over the wavelength range λpeak ≈ 510-1100 nm. The experimental sensitivity of the sensor permits diagnosis of glucosuria in the urine samples of diabetic patients with an improved performance compared to commercial high-throughput urinalysis devices. The sensor response was achieved within 5 min, reset to baseline in ∼10 s. It is anticipated that this sensing platform will have implications for the development of reusable, equipment-free colorimetric point-of-care diagnostic devices for diabetes screening.
|Number of pages||7|
|Publication status||Published - 11 Jun 2014|