Reusable, robust, and accurate laser-generated photonic nanosensor

Research output: Contribution to journalArticlepeer-review

Authors

  • Yunuen Montelongo
  • Fernando Da Cruz Vasconcellos
  • J. L. Martinez-Hurtado
  • Sankalpa Neupane
  • Malik M. Qasim
  • Jeffrey Blyth
  • Keith Burling
  • J. Bryan Carmody
  • Mark Evans
  • Timothy D. Wilkinson
  • Lauro T. Kubota
  • Michael J. Monteiro
  • Christopher R. Lowe

Colleges, School and Institutes

External organisations

  • Cambridge University Hospitals NHS Foundation Trust
  • Universidade Estadual de Campinas
  • The University of Queensland
  • University of Cambridge
  • Department of Pediatrics, Division of Nephrology, Eastern Virginia Medical School
  • National Institute of Science and Technology of Bioanalytics, Institute of Chemistry, University of Campinas

Abstract

Developing noninvasive and accurate diagnostics that are easily manufactured, robust, and reusable will provide monitoring of high-risk individuals in any clinical or point-of-care environment. We have developed a clinically relevant optical glucose nanosensor that can be reused at least 400 times without a compromise in accuracy. The use of a single 6 ns laser (λ = 532 nm, 200 mJ) pulse rapidly produced off-axis Bragg diffraction gratings consisting of ordered silver nanoparticles embedded within a phenylboronic acid-functionalized hydrogel. This sensor exhibited reversible large wavelength shifts and diffracted the spectrum of narrow-band light over the wavelength range λpeak ≈ 510-1100 nm. The experimental sensitivity of the sensor permits diagnosis of glucosuria in the urine samples of diabetic patients with an improved performance compared to commercial high-throughput urinalysis devices. The sensor response was achieved within 5 min, reset to baseline in ∼10 s. It is anticipated that this sensing platform will have implications for the development of reusable, equipment-free colorimetric point-of-care diagnostic devices for diabetes screening.

Details

Original languageEnglish
Pages (from-to)3587-3593
Number of pages7
JournalNano Letters
Volume14
Issue number6
Publication statusPublished - 11 Jun 2014

Keywords

  • diagnostics, glucose sensing, nanoparticles, Photonic sensors, point-of-care