Resistance to and synthesis of the antibiotic mupirocin

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Resistance to and synthesis of the antibiotic mupirocin. / Thomas, Christopher; Hothersall, Joanne; Willis, CL; Simpson, TJ.

In: Nature Reviews Microbiology, Vol. 8, No. 4, 01.04.2010, p. 281-289.

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@article{f3b85c005dcc4703836bc84f46cae911,
title = "Resistance to and synthesis of the antibiotic mupirocin",
abstract = "Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out by a combination of type I multifunctional polyketide synthases and tailoring enzymes encoded in a 75 kb gene cluster. Chemical synthesis has also been achieved. This knowledge should allow the synthesis of new and modified antibiotics for the future.",
author = "Christopher Thomas and Joanne Hothersall and CL Willis and TJ Simpson",
year = "2010",
month = apr,
day = "1",
doi = "10.1038/nrmicro2278",
language = "English",
volume = "8",
pages = "281--289",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Resistance to and synthesis of the antibiotic mupirocin

AU - Thomas, Christopher

AU - Hothersall, Joanne

AU - Willis, CL

AU - Simpson, TJ

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out by a combination of type I multifunctional polyketide synthases and tailoring enzymes encoded in a 75 kb gene cluster. Chemical synthesis has also been achieved. This knowledge should allow the synthesis of new and modified antibiotics for the future.

AB - Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out by a combination of type I multifunctional polyketide synthases and tailoring enzymes encoded in a 75 kb gene cluster. Chemical synthesis has also been achieved. This knowledge should allow the synthesis of new and modified antibiotics for the future.

U2 - 10.1038/nrmicro2278

DO - 10.1038/nrmicro2278

M3 - Article

C2 - 20190824

VL - 8

SP - 281

EP - 289

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 4

ER -