Replication study of SNP associations for colorectal cancer in Hong Kong Chinese

JW Ho; SC Choi; YF Lee; TC Hui; SS Cherny; MM Garcia-Barcelo; L Carvajal-Carmona; R Liu; SH To; TK Yau; CC Chung; CC Yau; SM Hui; PY Lau; CH Yuen; YW Wong; S Ho; SS Fung; IP Tomlinson; RS Houlston; Kar Cheng; PC Sham

doi:10.1038/sj.bjc.6605977

Replication study of SNP associations for colorectal cancer in Hong Kong Chinese

JW Ho, SC Choi, YF Lee, TC Hui, SS Cherny, MM Garcia-Barcelo, L Carvajal-Carmona, R Liu, SH To, TK Yau, CC Chung, CC Yau, SM Hui, PY Lau, CH Yuen, YW Wong, S Ho, SS Fung, IP Tomlinson, RS HoulstonKar Cheng, PC Sham

Research output: Contribution to journal › Article

38 Citations (Scopus)

Abstract

BACKGROUND: Recent genome-wide association studies of colorectal cancer (CRC) have identified common single-nucleotide polymorphisms (SNPs) mapping to 10 independent loci that confer modest increased risk. These studies have been conducted in European populations and it is unclear whether these observations generalise to populations with different ethnicities and rates of CRC. METHODS: An association study was performed on 892 CRC cases and 890 controls recruited from the Hong Kong Chinese population, genotyping 32 SNPs, which were either associated with CRC in previous studies or are in close proximity to previously reported risk SNPs. RESULTS: Twelve of the SNPs showed evidence of an association. The strongest associations were provided by rs10795668 on 10p14, rs4779584 on 15q14 and rs12953717 on 18q21.2. There was significant linear association between CRC risk and the number of independent risk variants possessed by an individual (P 2.29 x 10(-5)). CONCLUSION: These results indicate that some previously reported SNP associations also impact on CRC risk in the Chinese population. Possible reasons for failure of replication for some loci include inadequate study power, differences in allele frequency, linkage disequilibrium structure or effect size between populations. Our results suggest that many associations for CRC are likely to generalise across populations. British Journal of Cancer (2011) 104, 369-375. doi: 10.1038/sj.bjc.6605977 www.bjcancer.com Published online 21 December 2010 (C) 2011 Cancer Research UK

Original language	English
Pages (from-to)	369-375
Number of pages	7
Journal	British Journal of Cancer
Volume	104
Issue number	2
DOIs	https://doi.org/10.1038/sj.bjc.6605977
Publication status	Published - 1 Jan 2011

Keywords

replication
association
genetic
colorectal cancer
Chinese

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/sj.bjc.6605977

Cite this

Ho, JW., Choi, SC., Lee, YF., Hui, TC., Cherny, SS., Garcia-Barcelo, MM., Carvajal-Carmona, L., Liu, R., To, SH., Yau, TK., Chung, CC., Yau, CC., Hui, SM., Lau, PY., Yuen, CH., Wong, YW., Ho, S., Fung, SS., Tomlinson, IP., ... Sham, PC. (2011). Replication study of SNP associations for colorectal cancer in Hong Kong Chinese. British Journal of Cancer, 104(2), 369-375. https://doi.org/10.1038/sj.bjc.6605977

@article{9b9ff8f887964cfb80507454e14996e1,

title = "Replication study of SNP associations for colorectal cancer in Hong Kong Chinese",

abstract = "BACKGROUND: Recent genome-wide association studies of colorectal cancer (CRC) have identified common single-nucleotide polymorphisms (SNPs) mapping to 10 independent loci that confer modest increased risk. These studies have been conducted in European populations and it is unclear whether these observations generalise to populations with different ethnicities and rates of CRC. METHODS: An association study was performed on 892 CRC cases and 890 controls recruited from the Hong Kong Chinese population, genotyping 32 SNPs, which were either associated with CRC in previous studies or are in close proximity to previously reported risk SNPs. RESULTS: Twelve of the SNPs showed evidence of an association. The strongest associations were provided by rs10795668 on 10p14, rs4779584 on 15q14 and rs12953717 on 18q21.2. There was significant linear association between CRC risk and the number of independent risk variants possessed by an individual (P 2.29 x 10(-5)). CONCLUSION: These results indicate that some previously reported SNP associations also impact on CRC risk in the Chinese population. Possible reasons for failure of replication for some loci include inadequate study power, differences in allele frequency, linkage disequilibrium structure or effect size between populations. Our results suggest that many associations for CRC are likely to generalise across populations. British Journal of Cancer (2011) 104, 369-375. doi: 10.1038/sj.bjc.6605977 www.bjcancer.com Published online 21 December 2010 (C) 2011 Cancer Research UK",

keywords = "replication, association, genetic, colorectal cancer, Chinese",

author = "JW Ho and SC Choi and YF Lee and TC Hui and SS Cherny and MM Garcia-Barcelo and L Carvajal-Carmona and R Liu and SH To and TK Yau and CC Chung and CC Yau and SM Hui and PY Lau and CH Yuen and YW Wong and S Ho and SS Fung and IP Tomlinson and RS Houlston and Kar Cheng and PC Sham",

year = "2011",

month = jan,

day = "1",

doi = "10.1038/sj.bjc.6605977",

language = "English",

volume = "104",

pages = "369--375",

journal = "British Journal of Cancer",

publisher = "Cancer Research UK",

number = "2",

}

Ho, JW, Choi, SC, Lee, YF, Hui, TC, Cherny, SS, Garcia-Barcelo, MM, Carvajal-Carmona, L, Liu, R, To, SH, Yau, TK, Chung, CC, Yau, CC, Hui, SM, Lau, PY, Yuen, CH, Wong, YW, Ho, S, Fung, SS, Tomlinson, IP, Houlston, RS, Cheng, K & Sham, PC 2011, 'Replication study of SNP associations for colorectal cancer in Hong Kong Chinese', British Journal of Cancer, vol. 104, no. 2, pp. 369-375. https://doi.org/10.1038/sj.bjc.6605977

TY - JOUR

T1 - Replication study of SNP associations for colorectal cancer in Hong Kong Chinese

AU - Ho, JW

AU - Choi, SC

AU - Lee, YF

AU - Hui, TC

AU - Cherny, SS

AU - Garcia-Barcelo, MM

AU - Carvajal-Carmona, L

AU - Liu, R

AU - To, SH

AU - Yau, TK

AU - Chung, CC

AU - Yau, CC

AU - Hui, SM

AU - Lau, PY

AU - Yuen, CH

AU - Wong, YW

AU - Ho, S

AU - Fung, SS

AU - Tomlinson, IP

AU - Houlston, RS

AU - Cheng, Kar

AU - Sham, PC

PY - 2011/1/1

Y1 - 2011/1/1

N2 - BACKGROUND: Recent genome-wide association studies of colorectal cancer (CRC) have identified common single-nucleotide polymorphisms (SNPs) mapping to 10 independent loci that confer modest increased risk. These studies have been conducted in European populations and it is unclear whether these observations generalise to populations with different ethnicities and rates of CRC. METHODS: An association study was performed on 892 CRC cases and 890 controls recruited from the Hong Kong Chinese population, genotyping 32 SNPs, which were either associated with CRC in previous studies or are in close proximity to previously reported risk SNPs. RESULTS: Twelve of the SNPs showed evidence of an association. The strongest associations were provided by rs10795668 on 10p14, rs4779584 on 15q14 and rs12953717 on 18q21.2. There was significant linear association between CRC risk and the number of independent risk variants possessed by an individual (P 2.29 x 10(-5)). CONCLUSION: These results indicate that some previously reported SNP associations also impact on CRC risk in the Chinese population. Possible reasons for failure of replication for some loci include inadequate study power, differences in allele frequency, linkage disequilibrium structure or effect size between populations. Our results suggest that many associations for CRC are likely to generalise across populations. British Journal of Cancer (2011) 104, 369-375. doi: 10.1038/sj.bjc.6605977 www.bjcancer.com Published online 21 December 2010 (C) 2011 Cancer Research UK

AB - BACKGROUND: Recent genome-wide association studies of colorectal cancer (CRC) have identified common single-nucleotide polymorphisms (SNPs) mapping to 10 independent loci that confer modest increased risk. These studies have been conducted in European populations and it is unclear whether these observations generalise to populations with different ethnicities and rates of CRC. METHODS: An association study was performed on 892 CRC cases and 890 controls recruited from the Hong Kong Chinese population, genotyping 32 SNPs, which were either associated with CRC in previous studies or are in close proximity to previously reported risk SNPs. RESULTS: Twelve of the SNPs showed evidence of an association. The strongest associations were provided by rs10795668 on 10p14, rs4779584 on 15q14 and rs12953717 on 18q21.2. There was significant linear association between CRC risk and the number of independent risk variants possessed by an individual (P 2.29 x 10(-5)). CONCLUSION: These results indicate that some previously reported SNP associations also impact on CRC risk in the Chinese population. Possible reasons for failure of replication for some loci include inadequate study power, differences in allele frequency, linkage disequilibrium structure or effect size between populations. Our results suggest that many associations for CRC are likely to generalise across populations. British Journal of Cancer (2011) 104, 369-375. doi: 10.1038/sj.bjc.6605977 www.bjcancer.com Published online 21 December 2010 (C) 2011 Cancer Research UK

KW - replication

KW - association

KW - genetic

KW - colorectal cancer

KW - Chinese

U2 - 10.1038/sj.bjc.6605977

DO - 10.1038/sj.bjc.6605977

M3 - Article

C2 - 21179028

VL - 104

SP - 369

EP - 375

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 2

ER -

Replication study of SNP associations for colorectal cancer in Hong Kong Chinese

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this