Repeat-element driven activation of proto-oncogenes in human malignancies

B Lamprecht; Constanze Bonifer; S Mathas

doi:10.4161/cc.9.21.13682

Repeat-element driven activation of proto-oncogenes in human malignancies

B Lamprecht, Constanze Bonifer, S Mathas

Cancer and Genomic Sciences

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

Recent data demonstrated that the aberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. This article summarizes these results and gives an outlook on the impact of these findings on the pathogenesis and therapy of human cancer.

Original language	English
Pages (from-to)	4276-4281
Number of pages	6
Journal	Cell Cycle
Volume	9
Issue number	21
DOIs	https://doi.org/10.4161/cc.9.21.13682
Publication status	Published - 1 Nov 2010

Keywords

DNA methylation
LTR
Hodgkin lymphoma
epigenetic reprogramming
CSF-1 receptor

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cc.9.21.13682

Cite this

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title = "Repeat-element driven activation of proto-oncogenes in human malignancies",

abstract = "Recent data demonstrated that the aberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. This article summarizes these results and gives an outlook on the impact of these findings on the pathogenesis and therapy of human cancer.",

keywords = "DNA methylation, LTR, Hodgkin lymphoma, epigenetic reprogramming, CSF-1 receptor",

author = "B Lamprecht and Constanze Bonifer and S Mathas",

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T1 - Repeat-element driven activation of proto-oncogenes in human malignancies

AU - Lamprecht, B

AU - Bonifer, Constanze

AU - Mathas, S

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N2 - Recent data demonstrated that the aberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. This article summarizes these results and gives an outlook on the impact of these findings on the pathogenesis and therapy of human cancer.

AB - Recent data demonstrated that the aberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. This article summarizes these results and gives an outlook on the impact of these findings on the pathogenesis and therapy of human cancer.

KW - DNA methylation

KW - LTR

KW - Hodgkin lymphoma

KW - epigenetic reprogramming

KW - CSF-1 receptor

U2 - 10.4161/cc.9.21.13682

DO - 10.4161/cc.9.21.13682

M3 - Article

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SN - 1551-4005

VL - 9

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EP - 4281

JO - Cell Cycle

JF - Cell Cycle

IS - 21

ER -

Repeat-element driven activation of proto-oncogenes in human malignancies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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