Repeat-element driven activation of proto-oncogenes in human malignancies

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Recent data demonstrated that the aberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. This article summarizes these results and gives an outlook on the impact of these findings on the pathogenesis and therapy of human cancer.

Details

Original languageEnglish
Pages (from-to)4276-4281
Number of pages6
JournalCell Cycle
Volume9
Issue number21
Publication statusPublished - 1 Nov 2010

Keywords

  • DNA methylation, LTR, Hodgkin lymphoma, epigenetic reprogramming, CSF-1 receptor