Renal artery sympathetic denervation: observations from the UK experience

Research output: Contribution to journalArticle

Authors

  • Andrew S P Sharp
  • Justin E Davies
  • Melvin D Lobo
  • Clare L Bent
  • Patrick B Mark
  • Amy E Burchell
  • Simon D Thackray
  • William S McKane
  • Robert T Gerber
  • James R Wilkinson
  • Tarek F Antonios
  • Timothy W Doulton
  • Tiffany Patterson
  • Piers C Clifford
  • Alistair Lindsay
  • Graeme J Houston
  • Jonathan Freedman
  • Neelan Das
  • Anna M Belli
  • Mohamad Faris
  • Trevor J Cleveland
  • Angus K Nightingale
  • Awais Hameed
  • Kalaivani Mahadevan
  • Judith A Finegold
  • Adam N Mather
  • Terry Levy
  • Richard D'Souza
  • Peter Riley
  • Jonathan G Moss
  • Carlo Di Mario
  • Simon R Redwood
  • Andreas Baumbach
  • Mark J Caulfield
  • Indranil Dasgupta

Colleges, School and Institutes

Abstract

BACKGROUND: Renal denervation (RDN) may lower blood pressure (BP); however, it is unclear whether medication changes may be confounding results. Furthermore, limited data exist on pattern of ambulatory blood pressure (ABP) response-particularly in those prescribed aldosterone antagonists at the time of RDN.

METHODS: We examined all patients treated with RDN for treatment-resistant hypertension in 18 UK centres.

RESULTS: Results from 253 patients treated with five technologies are shown. Pre-procedural mean office BP (OBP) was 185/102 mmHg (SD 26/19; n = 253) and mean daytime ABP was 170/98 mmHg (SD 22/16; n = 186). Median number of antihypertensive drugs was 5.0: 96 % ACEi/ARB; 86 % thiazide/loop diuretic and 55 % aldosterone antagonist. OBP, available in 90 % at 11 months follow-up, was 163/93 mmHg (reduction of 22/9 mmHg). ABP, available in 70 % at 8.5 months follow-up, was 158/91 mmHg (fall of 12/7 mmHg). Mean drug changes post RDN were: 0.36 drugs added, 0.91 withdrawn. Dose changes appeared neutral. Quartile analysis by starting ABP showed mean reductions in systolic ABP after RDN of: 0.4; 6.5; 14.5 and 22.1 mmHg, respectively (p < 0.001 for trend). Use of aldosterone antagonist did not predict response (p > 0.2).

CONCLUSION: In 253 patients treated with RDN, office BP fell by 22/9 mmHg. Ambulatory BP fell by 12/7 mmHg, though little response was seen in the lowermost quartile of starting blood pressure. Fall in BP was not explained by medication changes and aldosterone antagonist use did not affect response.

Details

Original languageEnglish
JournalClinical Research in Cardiology
Early online date22 Jan 2016
Publication statusE-pub ahead of print - 22 Jan 2016

Keywords

  • Hypertension, Sympathetic nervous system, Catheter ablation, Aldosterone