Remote control of glucose homeostasis in vivo using photopharmacology
Research output: Contribution to journal › Article
Colleges, School and Institutes
- Imperial College London
- Department of Chemistry, Ludwig-Maximilians-Universitat Muchen, and Munich Center for Integrated Protein Science, Butenandtstrasse 5-13, 81377 Muchen, Germany
Photopharmacology describes the use of light to precisely deliver drug activity in space and time. Such approaches promise to improve drug specificity by reducing off-target effects. As a proof-of-concept, we have subjected the fourth generation photoswitchable sulfonylurea JB253 to comprehensive toxicology assessment, including mutagenicity and maximum/repeated tolerated dose studies, as well as in vivo testing in rodents. Here, we show that JB253 is well-tolerated with minimal mutagenicity and can be used to optically-control glucose homeostasis in anesthetized mice following delivery of blue light to the pancreas. These studies provide the first demonstration that photopharmacology may one day be applicable to the light-guided treatment of type 2 diabetes and other metabolic disease states in vivo in humans.
|Publication status||Published - 22 Mar 2017|
- Potassium channels, Type 2 diabetes