Release of diacylglycerol-enriched vesicles from erythrocytes with increased intracellular [Ca2+]

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Colleges, School and Institutes

External organisations

  • Department of Biochemistry
  • Birmingham University


WHEN the intracellular Ca2+ concentration of human red cells was increased by treatment of the cells with A23187, a divalent cation ionophore, they changed shape from discocyte to echinocyte1-3 and the 1,2-diacylglycerol content of their membranes was increased2-4. In these experiments it seemed that microvesicles budded off from the microvillus-like projections on the echinocytes2,3. We have now isolated the microvesicles and examined their composition and structure.


Original languageEnglish
Pages (from-to)58-60
Number of pages3
Issue number5555
Publication statusPublished - 1 Dec 1976

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