Relationship between the anterior forebrain mesocircuit and the default mode network in the structural bases of disorders of consciousness

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Relationship between the anterior forebrain mesocircuit and the default mode network in the structural bases of disorders of consciousness. / Lant, Nicholas D; Gonzalez-Lara, Laura E; Owen, Adrian M; Fernández-Espejo, Davinia.

In: NeuroImage: Clinical, Vol. 10, 2016, p. 27-35.

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@article{893c2a65c2074f2aa7f569de7b9bb69a,
title = "Relationship between the anterior forebrain mesocircuit and the default mode network in the structural bases of disorders of consciousness",
abstract = "The specific neural bases of disorders of consciousness (DOC) are still not well understood. Some studies have suggested that functional and structural impairments in the default mode network may play a role in explaining these disorders. In contrast, others have proposed that dysfunctions in the anterior forebrain mesocircuit involving striatum, globus pallidus, and thalamus may be the main underlying mechanism. Here, we provide the first report of structural integrity of fiber tracts connecting the nodes of the mesocircuit and the default mode network in 8 patients with DOC. We found evidence of significant damage to subcortico-cortical and cortico-cortical fibers, which were more severe in vegetative state patients and correlated with clinical severity as determined by Coma Recovery Scale-Revised (CRS-R) scores. In contrast, fiber tracts interconnecting subcortical nodes were not significantly impaired. Lastly, we found significant damage in all fiber tracts connecting the precuneus with cortical and subcortical areas. Our results suggest a strong relationship between the default mode network - and most importantly the precuneus - and the anterior forebrain mesocircuit in the neural basis of the DOC.",
keywords = "Disorders of consciousness, Default mode network, Thalamus, Basal ganglia, Anterior forebrain mesocircuit, Precuneus, DTI, Tractography, white matter, traumatic brain injury, Hypoxic–ischemic brain injury, vegetative state, minimally conscious state",
author = "Lant, {Nicholas D} and Gonzalez-Lara, {Laura E} and Owen, {Adrian M} and Davinia Fern{\'a}ndez-Espejo",
year = "2016",
doi = "10.1016/j.nicl.2015.11.004",
language = "English",
volume = "10",
pages = "27--35",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Relationship between the anterior forebrain mesocircuit and the default mode network in the structural bases of disorders of consciousness

AU - Lant, Nicholas D

AU - Gonzalez-Lara, Laura E

AU - Owen, Adrian M

AU - Fernández-Espejo, Davinia

PY - 2016

Y1 - 2016

N2 - The specific neural bases of disorders of consciousness (DOC) are still not well understood. Some studies have suggested that functional and structural impairments in the default mode network may play a role in explaining these disorders. In contrast, others have proposed that dysfunctions in the anterior forebrain mesocircuit involving striatum, globus pallidus, and thalamus may be the main underlying mechanism. Here, we provide the first report of structural integrity of fiber tracts connecting the nodes of the mesocircuit and the default mode network in 8 patients with DOC. We found evidence of significant damage to subcortico-cortical and cortico-cortical fibers, which were more severe in vegetative state patients and correlated with clinical severity as determined by Coma Recovery Scale-Revised (CRS-R) scores. In contrast, fiber tracts interconnecting subcortical nodes were not significantly impaired. Lastly, we found significant damage in all fiber tracts connecting the precuneus with cortical and subcortical areas. Our results suggest a strong relationship between the default mode network - and most importantly the precuneus - and the anterior forebrain mesocircuit in the neural basis of the DOC.

AB - The specific neural bases of disorders of consciousness (DOC) are still not well understood. Some studies have suggested that functional and structural impairments in the default mode network may play a role in explaining these disorders. In contrast, others have proposed that dysfunctions in the anterior forebrain mesocircuit involving striatum, globus pallidus, and thalamus may be the main underlying mechanism. Here, we provide the first report of structural integrity of fiber tracts connecting the nodes of the mesocircuit and the default mode network in 8 patients with DOC. We found evidence of significant damage to subcortico-cortical and cortico-cortical fibers, which were more severe in vegetative state patients and correlated with clinical severity as determined by Coma Recovery Scale-Revised (CRS-R) scores. In contrast, fiber tracts interconnecting subcortical nodes were not significantly impaired. Lastly, we found significant damage in all fiber tracts connecting the precuneus with cortical and subcortical areas. Our results suggest a strong relationship between the default mode network - and most importantly the precuneus - and the anterior forebrain mesocircuit in the neural basis of the DOC.

KW - Disorders of consciousness

KW - Default mode network

KW - Thalamus

KW - Basal ganglia

KW - Anterior forebrain mesocircuit

KW - Precuneus

KW - DTI

KW - Tractography

KW - white matter

KW - traumatic brain injury

KW - Hypoxic–ischemic brain injury

KW - vegetative state

KW - minimally conscious state

U2 - 10.1016/j.nicl.2015.11.004

DO - 10.1016/j.nicl.2015.11.004

M3 - Article

C2 - 26693399

VL - 10

SP - 27

EP - 35

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

ER -