TY - JOUR
T1 - Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD
AU - Pan, Jing
AU - Xu, Lin
AU - Lam, Tai Hing
AU - Jiang, Chao Qiang
AU - Zhang, Wei Sen
AU - Zhu, Xiao-Feng
AU - Jin, Ya Li
AU - Thomas, G Neil
AU - Cheng, Kar
AU - Adab, Peymane
PY - 2018/5/21
Y1 - 2018/5/21
N2 - Background: Findings describing the relationship between pulmonary function and peripheral vascular function
have been inconclusive. We explored this relationship in Guangzhou Biobank Cohort Study-Cardiovascular
Subcohort (GBCS-CVD).
Methods: Brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were measured by a waveform
analyser, and pulmonary function by turbine flowmeter spirometry. Predicted forced expiratory volume in 1 s (FEV1)
and forced vital capacity (FVC) were derived using equations for Chinese. Regression analyses were used to investigate
the association.
Results: Of 1528 older Chinese, 980 (64.1%) had arterial stiffness (baPWV ≥1400 cm/s), but only 29 (1.9%) had
peripheral arterial disease (PAD) (ABI < 0.9). The mean (±standard deviation, SD) baPWV was 1547 (±298) cm/s
and mean (±SD) ABI 1.09 (±0.09). Before and after adjusting for potential confounders, baPWV was negatively
associated with FEV1 and FVC % predicted (% predicted = observed/predicted × 100%) (adjusted β: − 0.95 and
− 1.16 respectively, p < 0.05), and ABI was marginally non-significantly positively associated with FEV1% predicted
(adjusted β 0.02, p = 0.32) and FVC% predicted (adjusted β 0.02, p = 0.18). Compared to participants in the highest
tertile of pulmonary function, those in the lowest had higher risk of arterial stiffness (adjusted odds ratio (AOR) 1.
51, 95% CI 1.09–2.10 for FEV1 and AOR 1.69, 95% CI 1.22–2.33 for FVC), but the higher risk of PAD was marginally
non-significant (AOR 1.64, p = 0.42 for FEV1 and AOR 1.65, p = 0.24 for FVC).
Conclusion: In older relatively healthy normal weight Chinese, pulmonary function was inversely dose-dependently
associated with arterial stiffness, while the association with PAD was much weaker.
Keywords: Pulmonary function, Arterial stiffness, Peripheral arterial disease (PAD), Vascular function
AB - Background: Findings describing the relationship between pulmonary function and peripheral vascular function
have been inconclusive. We explored this relationship in Guangzhou Biobank Cohort Study-Cardiovascular
Subcohort (GBCS-CVD).
Methods: Brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were measured by a waveform
analyser, and pulmonary function by turbine flowmeter spirometry. Predicted forced expiratory volume in 1 s (FEV1)
and forced vital capacity (FVC) were derived using equations for Chinese. Regression analyses were used to investigate
the association.
Results: Of 1528 older Chinese, 980 (64.1%) had arterial stiffness (baPWV ≥1400 cm/s), but only 29 (1.9%) had
peripheral arterial disease (PAD) (ABI < 0.9). The mean (±standard deviation, SD) baPWV was 1547 (±298) cm/s
and mean (±SD) ABI 1.09 (±0.09). Before and after adjusting for potential confounders, baPWV was negatively
associated with FEV1 and FVC % predicted (% predicted = observed/predicted × 100%) (adjusted β: − 0.95 and
− 1.16 respectively, p < 0.05), and ABI was marginally non-significantly positively associated with FEV1% predicted
(adjusted β 0.02, p = 0.32) and FVC% predicted (adjusted β 0.02, p = 0.18). Compared to participants in the highest
tertile of pulmonary function, those in the lowest had higher risk of arterial stiffness (adjusted odds ratio (AOR) 1.
51, 95% CI 1.09–2.10 for FEV1 and AOR 1.69, 95% CI 1.22–2.33 for FVC), but the higher risk of PAD was marginally
non-significant (AOR 1.64, p = 0.42 for FEV1 and AOR 1.65, p = 0.24 for FVC).
Conclusion: In older relatively healthy normal weight Chinese, pulmonary function was inversely dose-dependently
associated with arterial stiffness, while the association with PAD was much weaker.
Keywords: Pulmonary function, Arterial stiffness, Peripheral arterial disease (PAD), Vascular function
KW - Pulmonary function
KW - Arterial stiffness
KW - Peripheral arterial disease (PAD
KW - Vascular function
U2 - 10.1186/s12890-018-0649-x
DO - 10.1186/s12890-018-0649-x
M3 - Article
SN - 1471-2466
VL - 18
JO - BMC Pulmonary Medicine
JF - BMC Pulmonary Medicine
IS - 74
ER -