Regulatory opportunities to encourage technology solutions to antibacterial drug resistance

Research output: Contribution to journalArticle

Authors

  • Roger Finch
  • BSAC Working Party on The Urgent Need: Regenerating Antibacterial Drug Discovery and Development
  • Laura Piddock

Colleges, School and Institutes

Abstract

Regulatory agencies play a critical role in the licensing of new antimicrobial agents. To address the pivotal role played by regulatory agencies, particularly in the context of a paucity of new drugs active against bacteria resistant to currently available drugs, the BSAC formed the 'Urgent Need' Working Party to address the regeneration of antibacterial drug discovery and development. The Working Party identified a number of issues, including: increased application of pharmacokinetic/pharmacodynamic principles to expedite drug development; the need to prioritize licensing of drugs (including 'orphan' drugs) active in life-threatening infections; and expansion of the use of surrogate markers and rapid point of care diagnostics to facilitate drug development.

Details

Original languageEnglish
Pages (from-to)1945-7
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Volume66
Issue number9
Publication statusPublished - Sep 2011

Keywords

  • Anti-Bacterial Agents, Bacterial Infections, Diffusion of Innovation, Drug Design, Drug Resistance, Bacterial, Humans, Legislation, Drug, Microbiology, Technology