Regulation of WASP: PIP2 Pipped by Toca-1?
Research output: Contribution to journal › Review article
Colleges, School and Institutes
Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP. This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility.
|Number of pages||2|
|Publication status||Published - 1 Jan 2004|