Regulation of Unperturbed DNA Replication by Ubiquitylation

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Regulation of Unperturbed DNA Replication by Ubiquitylation. / Moreno, Sara Priego; Gambus, Agnieszka.

In: Genes, Vol. 6, No. 3, 25.06.2015, p. 451-468.

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@article{02491957a30046fd8d0795e68c78f11e,
title = "Regulation of Unperturbed DNA Replication by Ubiquitylation",
abstract = "Posttranslational modification of proteins by means of attachment of a small globular protein ubiquitin (i.e., ubiquitylation) represents one of the most abundant and versatile mechanisms of protein regulation employed by eukaryotic cells. Ubiquitylation influences almost every cellular process and its key role in coordination of the DNA damage response is well established. In this review we focus, however, on the ways ubiquitylation controls the process of unperturbed DNA replication. We summarise the accumulated knowledge showing the leading role of ubiquitin driven protein degradation in setting up conditions favourable for replication origin licensing and S-phase entry. Importantly, we also present the emerging major role of ubiquitylation in coordination of the active DNA replication process: preventing re-replication, regulating the progression of DNA replication forks, chromatin re-establishment and disassembly of the replisome at the termination of replication forks.",
keywords = "DNA replication , replisome, posttranslational modification, termination, ubiquitylation, proteasomal degradation, re-replication",
author = "Moreno, {Sara Priego} and Agnieszka Gambus",
year = "2015",
month = jun,
day = "25",
doi = "10.3390/genes6030451",
language = "English",
volume = "6",
pages = "451--468",
journal = "Genes",
issn = "2073-4425",
publisher = "MDPI",
number = "3",

}

RIS

TY - JOUR

T1 - Regulation of Unperturbed DNA Replication by Ubiquitylation

AU - Moreno, Sara Priego

AU - Gambus, Agnieszka

PY - 2015/6/25

Y1 - 2015/6/25

N2 - Posttranslational modification of proteins by means of attachment of a small globular protein ubiquitin (i.e., ubiquitylation) represents one of the most abundant and versatile mechanisms of protein regulation employed by eukaryotic cells. Ubiquitylation influences almost every cellular process and its key role in coordination of the DNA damage response is well established. In this review we focus, however, on the ways ubiquitylation controls the process of unperturbed DNA replication. We summarise the accumulated knowledge showing the leading role of ubiquitin driven protein degradation in setting up conditions favourable for replication origin licensing and S-phase entry. Importantly, we also present the emerging major role of ubiquitylation in coordination of the active DNA replication process: preventing re-replication, regulating the progression of DNA replication forks, chromatin re-establishment and disassembly of the replisome at the termination of replication forks.

AB - Posttranslational modification of proteins by means of attachment of a small globular protein ubiquitin (i.e., ubiquitylation) represents one of the most abundant and versatile mechanisms of protein regulation employed by eukaryotic cells. Ubiquitylation influences almost every cellular process and its key role in coordination of the DNA damage response is well established. In this review we focus, however, on the ways ubiquitylation controls the process of unperturbed DNA replication. We summarise the accumulated knowledge showing the leading role of ubiquitin driven protein degradation in setting up conditions favourable for replication origin licensing and S-phase entry. Importantly, we also present the emerging major role of ubiquitylation in coordination of the active DNA replication process: preventing re-replication, regulating the progression of DNA replication forks, chromatin re-establishment and disassembly of the replisome at the termination of replication forks.

KW - DNA replication

KW - replisome

KW - posttranslational modification

KW - termination

KW - ubiquitylation

KW - proteasomal degradation

KW - re-replication

U2 - 10.3390/genes6030451

DO - 10.3390/genes6030451

M3 - Article

C2 - 26121093

VL - 6

SP - 451

EP - 468

JO - Genes

JF - Genes

SN - 2073-4425

IS - 3

ER -