Regulation of tumour necrosis factor α mRNA stability by the mitogen-activated protein kinase p38 signalling cascade

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Regulation of tumour necrosis factor α mRNA stability by the mitogen-activated protein kinase p38 signalling cascade. / Brook, Matthew; Sully, Gareth; Clark, Andrew R.; Saklatvala, Jeremy.

In: FEBS Letters, Vol. 483, No. 1, 13.10.2000, p. 57-61.

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@article{aa7c953f7bea4acb90b93859e7f719fc,
title = "Regulation of tumour necrosis factor α mRNA stability by the mitogen-activated protein kinase p38 signalling cascade",
abstract = "The translation of tumour necrosis factor α (TNFα) mRNA is regulated by the stress-activated protein kinase p38, which also controls the stability of several pro-inflammatory mRNAs. The regulation of TNFα gene expression in a mouse macrophage cell line RAW264.7 was re-examined using an inhibitor of stress-activated protein kinases. Stimulation of these cells with bacterial lipopolysaccharide resulted in stabilisation of TNFα mRNA, which was reversed by specific inhibition of p38. An adenosine/uridine-rich element from the TNFα 3' untranslated region conferred p38-sensitive decay in a tetracycline-regulated mRNA stability assay. Therefore the p38 pathway also controls TNFα mRNA turnover. Copyright (C) 2000 Federation of European Biochemical Societies.",
keywords = "Lipopolysaccharide, Macrophage, Mitogen-activated protein kinase p38, mRNA stability, Translation, Tumor necrosis factor α",
author = "Matthew Brook and Gareth Sully and Clark, {Andrew R.} and Jeremy Saklatvala",
year = "2000",
month = oct,
day = "13",
doi = "10.1016/S0014-5793(00)02084-6",
language = "English",
volume = "483",
pages = "57--61",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Regulation of tumour necrosis factor α mRNA stability by the mitogen-activated protein kinase p38 signalling cascade

AU - Brook, Matthew

AU - Sully, Gareth

AU - Clark, Andrew R.

AU - Saklatvala, Jeremy

PY - 2000/10/13

Y1 - 2000/10/13

N2 - The translation of tumour necrosis factor α (TNFα) mRNA is regulated by the stress-activated protein kinase p38, which also controls the stability of several pro-inflammatory mRNAs. The regulation of TNFα gene expression in a mouse macrophage cell line RAW264.7 was re-examined using an inhibitor of stress-activated protein kinases. Stimulation of these cells with bacterial lipopolysaccharide resulted in stabilisation of TNFα mRNA, which was reversed by specific inhibition of p38. An adenosine/uridine-rich element from the TNFα 3' untranslated region conferred p38-sensitive decay in a tetracycline-regulated mRNA stability assay. Therefore the p38 pathway also controls TNFα mRNA turnover. Copyright (C) 2000 Federation of European Biochemical Societies.

AB - The translation of tumour necrosis factor α (TNFα) mRNA is regulated by the stress-activated protein kinase p38, which also controls the stability of several pro-inflammatory mRNAs. The regulation of TNFα gene expression in a mouse macrophage cell line RAW264.7 was re-examined using an inhibitor of stress-activated protein kinases. Stimulation of these cells with bacterial lipopolysaccharide resulted in stabilisation of TNFα mRNA, which was reversed by specific inhibition of p38. An adenosine/uridine-rich element from the TNFα 3' untranslated region conferred p38-sensitive decay in a tetracycline-regulated mRNA stability assay. Therefore the p38 pathway also controls TNFα mRNA turnover. Copyright (C) 2000 Federation of European Biochemical Societies.

KW - Lipopolysaccharide

KW - Macrophage

KW - Mitogen-activated protein kinase p38

KW - mRNA stability

KW - Translation

KW - Tumor necrosis factor α

UR - http://www.scopus.com/inward/record.url?scp=0034644837&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(00)02084-6

DO - 10.1016/S0014-5793(00)02084-6

M3 - Article

C2 - 11033356

AN - SCOPUS:0034644837

VL - 483

SP - 57

EP - 61

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1

ER -