Regulation of the extrarenal CYP27B1-hydroxylase

Research output: Contribution to journalArticle

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Regulation of the extrarenal CYP27B1-hydroxylase. / Adams, John S; Rafison, Brandon; Witzel, Sten; Reyes, Rachel E; Shieh, Albert; Chun, Rene; Zavala, Kathryn; Hewison, Martin; Liu, Philip T.

In: The Journal of Steroid Biochemistry and Molecular Biology, Vol. 144 Pt A, 10.2014, p. 22-7.

Research output: Contribution to journalArticle

Harvard

Adams, JS, Rafison, B, Witzel, S, Reyes, RE, Shieh, A, Chun, R, Zavala, K, Hewison, M & Liu, PT 2014, 'Regulation of the extrarenal CYP27B1-hydroxylase', The Journal of Steroid Biochemistry and Molecular Biology, vol. 144 Pt A, pp. 22-7. https://doi.org/10.1016/j.jsbmb.2013.12.009

APA

Adams, J. S., Rafison, B., Witzel, S., Reyes, R. E., Shieh, A., Chun, R., Zavala, K., Hewison, M., & Liu, P. T. (2014). Regulation of the extrarenal CYP27B1-hydroxylase. The Journal of Steroid Biochemistry and Molecular Biology, 144 Pt A, 22-7. https://doi.org/10.1016/j.jsbmb.2013.12.009

Vancouver

Author

Adams, John S ; Rafison, Brandon ; Witzel, Sten ; Reyes, Rachel E ; Shieh, Albert ; Chun, Rene ; Zavala, Kathryn ; Hewison, Martin ; Liu, Philip T. / Regulation of the extrarenal CYP27B1-hydroxylase. In: The Journal of Steroid Biochemistry and Molecular Biology. 2014 ; Vol. 144 Pt A. pp. 22-7.

Bibtex

@article{680c39f0196e4734b4316d30ff4eac9e,
title = "Regulation of the extrarenal CYP27B1-hydroxylase",
abstract = "Provided here is a collective review of research on the extrarenal CYP27B1-hydroxylase that shapes our current and expanding vision of the role this enzyme plays in the intracrinology and paracrinology, as opposed to the traditional endocrinology, of vitamin D to regulate the innate and adaptive immune responses, particularly in human granuloma-forming diseases like tuberculosis. Special emphasis is placed on soluble factors (i.e., cytokines) in the local microenvironment of these human diseases that coordinate amplification and feedback inhibition of the macrophage CYP27B1-hydroxylase. Principal among these factors are Type I and Type II interferons (IFNs); the Type II IFN, IFN-γ, stimulates the production of 1,25-dihydroxyvitamin D (1,25(OH)2D) from 25-hydroxyvitamin D (25OHD) by the granuloma-forming disease-activated macrophage, while the Type I IFNs, IFN-α and IFN-β, block the hydroxylation reaction. The Type I IFN response is associated with more aggressive disease, while the Type II IFN response, the one that promotes 1,25(OH)2D production by the macrophage, is associated with more confined disease. Tilting the balance in the human immune response toward a confined disease phenotype is enabled by the presence of sufficient extracellular 25OHD to modulate IFN-γ-promoted and substrate 25OH-driven intracellular synthesis of 1,25(OH)2D. This article is part of a Special Issue entitled 'Vitamin D Workshop'.",
keywords = "25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Animals, Gene Expression Regulation, Humans, Macrophages, Receptors, Calcitriol, Transcription, Genetic, Vitamin D",
author = "Adams, {John S} and Brandon Rafison and Sten Witzel and Reyes, {Rachel E} and Albert Shieh and Rene Chun and Kathryn Zavala and Martin Hewison and Liu, {Philip T}",
note = "Copyright {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
month = oct,
doi = "10.1016/j.jsbmb.2013.12.009",
language = "English",
volume = "144 Pt A",
pages = "22--7",
journal = "The Journal of Steroid Biochemistry and Molecular Biology",
issn = "0960-0760",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Regulation of the extrarenal CYP27B1-hydroxylase

AU - Adams, John S

AU - Rafison, Brandon

AU - Witzel, Sten

AU - Reyes, Rachel E

AU - Shieh, Albert

AU - Chun, Rene

AU - Zavala, Kathryn

AU - Hewison, Martin

AU - Liu, Philip T

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2014/10

Y1 - 2014/10

N2 - Provided here is a collective review of research on the extrarenal CYP27B1-hydroxylase that shapes our current and expanding vision of the role this enzyme plays in the intracrinology and paracrinology, as opposed to the traditional endocrinology, of vitamin D to regulate the innate and adaptive immune responses, particularly in human granuloma-forming diseases like tuberculosis. Special emphasis is placed on soluble factors (i.e., cytokines) in the local microenvironment of these human diseases that coordinate amplification and feedback inhibition of the macrophage CYP27B1-hydroxylase. Principal among these factors are Type I and Type II interferons (IFNs); the Type II IFN, IFN-γ, stimulates the production of 1,25-dihydroxyvitamin D (1,25(OH)2D) from 25-hydroxyvitamin D (25OHD) by the granuloma-forming disease-activated macrophage, while the Type I IFNs, IFN-α and IFN-β, block the hydroxylation reaction. The Type I IFN response is associated with more aggressive disease, while the Type II IFN response, the one that promotes 1,25(OH)2D production by the macrophage, is associated with more confined disease. Tilting the balance in the human immune response toward a confined disease phenotype is enabled by the presence of sufficient extracellular 25OHD to modulate IFN-γ-promoted and substrate 25OH-driven intracellular synthesis of 1,25(OH)2D. This article is part of a Special Issue entitled 'Vitamin D Workshop'.

AB - Provided here is a collective review of research on the extrarenal CYP27B1-hydroxylase that shapes our current and expanding vision of the role this enzyme plays in the intracrinology and paracrinology, as opposed to the traditional endocrinology, of vitamin D to regulate the innate and adaptive immune responses, particularly in human granuloma-forming diseases like tuberculosis. Special emphasis is placed on soluble factors (i.e., cytokines) in the local microenvironment of these human diseases that coordinate amplification and feedback inhibition of the macrophage CYP27B1-hydroxylase. Principal among these factors are Type I and Type II interferons (IFNs); the Type II IFN, IFN-γ, stimulates the production of 1,25-dihydroxyvitamin D (1,25(OH)2D) from 25-hydroxyvitamin D (25OHD) by the granuloma-forming disease-activated macrophage, while the Type I IFNs, IFN-α and IFN-β, block the hydroxylation reaction. The Type I IFN response is associated with more aggressive disease, while the Type II IFN response, the one that promotes 1,25(OH)2D production by the macrophage, is associated with more confined disease. Tilting the balance in the human immune response toward a confined disease phenotype is enabled by the presence of sufficient extracellular 25OHD to modulate IFN-γ-promoted and substrate 25OH-driven intracellular synthesis of 1,25(OH)2D. This article is part of a Special Issue entitled 'Vitamin D Workshop'.

KW - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase

KW - Animals

KW - Gene Expression Regulation

KW - Humans

KW - Macrophages

KW - Receptors, Calcitriol

KW - Transcription, Genetic

KW - Vitamin D

U2 - 10.1016/j.jsbmb.2013.12.009

DO - 10.1016/j.jsbmb.2013.12.009

M3 - Article

C2 - 24388948

VL - 144 Pt A

SP - 22

EP - 27

JO - The Journal of Steroid Biochemistry and Molecular Biology

JF - The Journal of Steroid Biochemistry and Molecular Biology

SN - 0960-0760

ER -