Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae

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Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae. / Weston, Natasha; Sharma, Prateek; Ricci, Vito; Piddock, Laura J V.

In: Research in Microbiology, 08.11.2017.

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@article{4dbe0a528d7843949946d69437279667,
title = "Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae",
abstract = "Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation-division (RND) family of efflux pumps is the most clinically significant, as it is associated with multidrug resistance. Expression of efflux systems is subject to multiple levels of regulation, involving local and global transcriptional regulation as well as post-transcriptional and post-translational regulation. The best-characterised RND system is AcrAB-TolC, which is present in Enterobacteriaceae. This review describes the current knowledge and new data about the regulation of the acrAB and tolC genes in Escherichia coli and Salmonella enterica.",
keywords = "Salmonella, Escherichia coli, AcrAB-TolC, Transcription, Induction, Multidrug resistance",
author = "Natasha Weston and Prateek Sharma and Vito Ricci and Piddock, {Laura J V}",
note = "Copyright {\textcopyright} 2017. Published by Elsevier Masson SAS.",
year = "2017",
month = nov,
day = "8",
doi = "10.1016/j.resmic.2017.10.005",
language = "English",
journal = "Research in Microbiology",
issn = "0923-2508",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae

AU - Weston, Natasha

AU - Sharma, Prateek

AU - Ricci, Vito

AU - Piddock, Laura J V

N1 - Copyright © 2017. Published by Elsevier Masson SAS.

PY - 2017/11/8

Y1 - 2017/11/8

N2 - Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation-division (RND) family of efflux pumps is the most clinically significant, as it is associated with multidrug resistance. Expression of efflux systems is subject to multiple levels of regulation, involving local and global transcriptional regulation as well as post-transcriptional and post-translational regulation. The best-characterised RND system is AcrAB-TolC, which is present in Enterobacteriaceae. This review describes the current knowledge and new data about the regulation of the acrAB and tolC genes in Escherichia coli and Salmonella enterica.

AB - Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation-division (RND) family of efflux pumps is the most clinically significant, as it is associated with multidrug resistance. Expression of efflux systems is subject to multiple levels of regulation, involving local and global transcriptional regulation as well as post-transcriptional and post-translational regulation. The best-characterised RND system is AcrAB-TolC, which is present in Enterobacteriaceae. This review describes the current knowledge and new data about the regulation of the acrAB and tolC genes in Escherichia coli and Salmonella enterica.

KW - Salmonella

KW - Escherichia coli

KW - AcrAB-TolC

KW - Transcription

KW - Induction

KW - Multidrug resistance

U2 - 10.1016/j.resmic.2017.10.005

DO - 10.1016/j.resmic.2017.10.005

M3 - Article

C2 - 29128373

JO - Research in Microbiology

JF - Research in Microbiology

SN - 0923-2508

ER -