Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae

Research output: Contribution to journalArticle

Colleges, School and Institutes

External organisations

  • Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom.
  • Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom. Electronic address: l.j.v.piddock@bham.ac.uk.

Abstract

Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation-division (RND) family of efflux pumps is the most clinically significant, as it is associated with multidrug resistance. Expression of efflux systems is subject to multiple levels of regulation, involving local and global transcriptional regulation as well as post-transcriptional and post-translational regulation. The best-characterised RND system is AcrAB-TolC, which is present in Enterobacteriaceae. This review describes the current knowledge and new data about the regulation of the acrAB and tolC genes in Escherichia coli and Salmonella enterica.

Details

Original languageEnglish
JournalResearch in Microbiology
Early online date8 Nov 2017
Publication statusE-pub ahead of print - 8 Nov 2017

Keywords

  • Salmonella, Escherichia coli, AcrAB-TolC, Transcription, Induction, Multidrug resistance