Regulation of cutaneous malignancy by gammadelta T cells

Research output: Contribution to journalArticlepeer-review

Standard

Regulation of cutaneous malignancy by gammadelta T cells. / Girardi, M; Oppenheim, D E; Steele, C R; Lewis, J M; Glusac, E; Filler, R; Hobby, P; Sutton, B; Tigelaar, R E; Hayday, A C.

In: Science, Vol. 294, No. 5542, 19.10.2001, p. 605-9.

Research output: Contribution to journalArticlepeer-review

Harvard

Girardi, M, Oppenheim, DE, Steele, CR, Lewis, JM, Glusac, E, Filler, R, Hobby, P, Sutton, B, Tigelaar, RE & Hayday, AC 2001, 'Regulation of cutaneous malignancy by gammadelta T cells', Science, vol. 294, no. 5542, pp. 605-9. https://doi.org/10.1126/science.1063916

APA

Girardi, M., Oppenheim, D. E., Steele, C. R., Lewis, J. M., Glusac, E., Filler, R., Hobby, P., Sutton, B., Tigelaar, R. E., & Hayday, A. C. (2001). Regulation of cutaneous malignancy by gammadelta T cells. Science, 294(5542), 605-9. https://doi.org/10.1126/science.1063916

Vancouver

Girardi M, Oppenheim DE, Steele CR, Lewis JM, Glusac E, Filler R et al. Regulation of cutaneous malignancy by gammadelta T cells. Science. 2001 Oct 19;294(5542):605-9. https://doi.org/10.1126/science.1063916

Author

Girardi, M ; Oppenheim, D E ; Steele, C R ; Lewis, J M ; Glusac, E ; Filler, R ; Hobby, P ; Sutton, B ; Tigelaar, R E ; Hayday, A C. / Regulation of cutaneous malignancy by gammadelta T cells. In: Science. 2001 ; Vol. 294, No. 5542. pp. 605-9.

Bibtex

@article{bb875b8131bd4e068b73c6cfa94449c9,
title = "Regulation of cutaneous malignancy by gammadelta T cells",
abstract = "The localization of gammadelta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gammadelta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis. After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex-related molecules structurally resembling human MICA. Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells. In vitro, skin-associated NKG2d+ gammadelta cells killed skin carcinoma cells by a mechanism that was sensitive to blocking NKG2d engagement. Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy.",
keywords = "Amino Acid Sequence, Animals, Carcinogens, Cell Line, Cytotoxicity, Immunologic, Dimerization, Epidermis, Epithelial Cells, Histocompatibility Antigens Class I, Humans, Immunologic Surveillance, Ligands, Membrane Proteins, Mice, Mice, Inbred C57BL, Minor Histocompatibility Antigens, Molecular Sequence Data, NK Cell Lectin-Like Receptor Subfamily K, Protein Conformation, Protein Folding, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Immunologic, Receptors, Natural Killer Cell, Recombinant Fusion Proteins, Reverse Transcriptase Polymerase Chain Reaction, Skin Neoplasms, T-Lymphocyte Subsets",
author = "M Girardi and Oppenheim, {D E} and Steele, {C R} and Lewis, {J M} and E Glusac and R Filler and P Hobby and B Sutton and Tigelaar, {R E} and Hayday, {A C}",
year = "2001",
month = oct,
day = "19",
doi = "10.1126/science.1063916",
language = "English",
volume = "294",
pages = "605--9",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5542",

}

RIS

TY - JOUR

T1 - Regulation of cutaneous malignancy by gammadelta T cells

AU - Girardi, M

AU - Oppenheim, D E

AU - Steele, C R

AU - Lewis, J M

AU - Glusac, E

AU - Filler, R

AU - Hobby, P

AU - Sutton, B

AU - Tigelaar, R E

AU - Hayday, A C

PY - 2001/10/19

Y1 - 2001/10/19

N2 - The localization of gammadelta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gammadelta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis. After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex-related molecules structurally resembling human MICA. Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells. In vitro, skin-associated NKG2d+ gammadelta cells killed skin carcinoma cells by a mechanism that was sensitive to blocking NKG2d engagement. Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy.

AB - The localization of gammadelta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gammadelta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis. After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex-related molecules structurally resembling human MICA. Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells. In vitro, skin-associated NKG2d+ gammadelta cells killed skin carcinoma cells by a mechanism that was sensitive to blocking NKG2d engagement. Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy.

KW - Amino Acid Sequence

KW - Animals

KW - Carcinogens

KW - Cell Line

KW - Cytotoxicity, Immunologic

KW - Dimerization

KW - Epidermis

KW - Epithelial Cells

KW - Histocompatibility Antigens Class I

KW - Humans

KW - Immunologic Surveillance

KW - Ligands

KW - Membrane Proteins

KW - Mice

KW - Mice, Inbred C57BL

KW - Minor Histocompatibility Antigens

KW - Molecular Sequence Data

KW - NK Cell Lectin-Like Receptor Subfamily K

KW - Protein Conformation

KW - Protein Folding

KW - Receptors, Antigen, T-Cell, alpha-beta

KW - Receptors, Antigen, T-Cell, gamma-delta

KW - Receptors, Immunologic

KW - Receptors, Natural Killer Cell

KW - Recombinant Fusion Proteins

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Skin Neoplasms

KW - T-Lymphocyte Subsets

U2 - 10.1126/science.1063916

DO - 10.1126/science.1063916

M3 - Article

C2 - 11567106

VL - 294

SP - 605

EP - 609

JO - Science

JF - Science

SN - 0036-8075

IS - 5542

ER -