Regulation of apoptosis and replicative senescence in CD8+T cell following acute viral infection

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Viral infections are characterised by a large expansion of CD8(+) effector T cells. Once generated, these T cells must be cleared and homeostasis re-established. In this review we describe two mechanisms, apoptosis and replicative senescence which are thought to play a vital role in this process. Apoptosis clears the unwanted T cells at the end of an immune response whereas replicative senescence prevents unlimited expansion of T cells. For successful memory to be produced T cells must avoid apoptosis and avoid replicative senescence.


Original languageEnglish
Pages (from-to)431-434
Number of pages4
Issue number5
Publication statusPublished - 1 Nov 2000


  • telomerase, telomeres, type 1 interferons, gamma common chain cytokines