Regulation and function of Ag43 (flu)

Research output: Contribution to journalArticlepeer-review

Standard

Regulation and function of Ag43 (flu). / van der Woude, Marjan W; Henderson, Ian R.

In: Annual Review of Microbiology, Vol. 62, 2008, p. 153-69.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

van der Woude, Marjan W ; Henderson, Ian R. / Regulation and function of Ag43 (flu). In: Annual Review of Microbiology. 2008 ; Vol. 62. pp. 153-69.

Bibtex

@article{3901ce931bff48b59929f98dc955561c,
title = "Regulation and function of Ag43 (flu)",
abstract = "Antigen 43 (Ag43) is an abundant outer membrane protein in Escherichia coli belonging to the autotransporter family. Structure-function relationships of Ag43 proposed on the basis of experimental work and in silico analysis are discussed in context of insights derived from molecular modeling. New sequence analysis sheds light on the phylogeny of the allelic variants of the Ag43-encoding gene and identifies two distinct families that appear to be distributed between specific pathogenic and commensal isolates. The molecular mechanism that controls expression by phase variation to create population heterogeneity is discussed. Proposed roles of Ag43 expression for E. coli are summarized and the studies are put into perspective regarding the role of allelic variants, genetic background of the bacterial strain, and control of expression by phase variation. We conclude that future studies need to take into account these variables to obtain a complete understanding of the contribution of Ag43 expression to E. coli biology.",
keywords = "Adhesins, Bacterial, Adhesins, Escherichia coli, Alleles, Amino Acid Sequence, Escherichia coli, Escherichia coli Infections, Escherichia coli Proteins, Gene Expression Regulation, Bacterial, Genes, Bacterial, Humans, Models, Molecular, Molecular Sequence Data, Phylogeny, Protein Conformation, Sequence Homology, Amino Acid, Urinary Tract Infections",
author = "{van der Woude}, {Marjan W} and Henderson, {Ian R}",
year = "2008",
doi = "10.1146/annurev.micro.62.081307.162938",
language = "English",
volume = "62",
pages = "153--69",
journal = "Annual Review of Microbiology",
issn = "0066-4227",
publisher = "Annual Reviews",

}

RIS

TY - JOUR

T1 - Regulation and function of Ag43 (flu)

AU - van der Woude, Marjan W

AU - Henderson, Ian R

PY - 2008

Y1 - 2008

N2 - Antigen 43 (Ag43) is an abundant outer membrane protein in Escherichia coli belonging to the autotransporter family. Structure-function relationships of Ag43 proposed on the basis of experimental work and in silico analysis are discussed in context of insights derived from molecular modeling. New sequence analysis sheds light on the phylogeny of the allelic variants of the Ag43-encoding gene and identifies two distinct families that appear to be distributed between specific pathogenic and commensal isolates. The molecular mechanism that controls expression by phase variation to create population heterogeneity is discussed. Proposed roles of Ag43 expression for E. coli are summarized and the studies are put into perspective regarding the role of allelic variants, genetic background of the bacterial strain, and control of expression by phase variation. We conclude that future studies need to take into account these variables to obtain a complete understanding of the contribution of Ag43 expression to E. coli biology.

AB - Antigen 43 (Ag43) is an abundant outer membrane protein in Escherichia coli belonging to the autotransporter family. Structure-function relationships of Ag43 proposed on the basis of experimental work and in silico analysis are discussed in context of insights derived from molecular modeling. New sequence analysis sheds light on the phylogeny of the allelic variants of the Ag43-encoding gene and identifies two distinct families that appear to be distributed between specific pathogenic and commensal isolates. The molecular mechanism that controls expression by phase variation to create population heterogeneity is discussed. Proposed roles of Ag43 expression for E. coli are summarized and the studies are put into perspective regarding the role of allelic variants, genetic background of the bacterial strain, and control of expression by phase variation. We conclude that future studies need to take into account these variables to obtain a complete understanding of the contribution of Ag43 expression to E. coli biology.

KW - Adhesins, Bacterial

KW - Adhesins, Escherichia coli

KW - Alleles

KW - Amino Acid Sequence

KW - Escherichia coli

KW - Escherichia coli Infections

KW - Escherichia coli Proteins

KW - Gene Expression Regulation, Bacterial

KW - Genes, Bacterial

KW - Humans

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Phylogeny

KW - Protein Conformation

KW - Sequence Homology, Amino Acid

KW - Urinary Tract Infections

U2 - 10.1146/annurev.micro.62.081307.162938

DO - 10.1146/annurev.micro.62.081307.162938

M3 - Article

C2 - 18785838

VL - 62

SP - 153

EP - 169

JO - Annual Review of Microbiology

JF - Annual Review of Microbiology

SN - 0066-4227

ER -