Regucalcin (RGN/SMP30) alters agonist- and thapsigargin- induced cytosolic [Ca2+] transients in cells by increasing SERCA Ca(2+)ATPase levels

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Regucalcin (RGN/SMP30) alters agonist- and thapsigargin- induced cytosolic [Ca2+] transients in cells by increasing SERCA Ca(2+)ATPase levels. / Lai, P; Yip, Nga; Michelangeli, Francesco.

In: FEBS Letters, Vol. 585, No. 14, 01.07.2011, p. 2291-2294.

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@article{8affd4d1bcc84c0a88f278654862bc45,
title = "Regucalcin (RGN/SMP30) alters agonist- and thapsigargin- induced cytosolic [Ca2+] transients in cells by increasing SERCA Ca(2+)ATPase levels",
abstract = "Regucalcin (RGN), also reported as senescence marker protein-30 (SMP30), plays a role in Ca2+ homeostasis by modulating a number of Ca2+-dependent proteins. RGN also plays a cyto-protective role and its decrease is linked to age-related diseases and cell death. This study shows that RGN reduces agonist (histamine)-induced Ca2+ transients in RGN(+) transfected COS-7 cells (RGN(+)) and also increases their Ca2+ storage capacity. These observations are explained by RGN(+) cells having increased mRNA and protein expression levels of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Therefore down-regulation of RGN expression may contribute to characteristics of age-dependent Ca2+ homeostasis dis-regulation, by decreasing SERCA levels. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",
keywords = "Calcium homeostasis, Regucalcin, Sarco/endo-plasmic reticulum Ca2+-ATPase, Aging, Senescence marker protein-30",
author = "P Lai and Nga Yip and Francesco Michelangeli",
year = "2011",
month = jul,
day = "1",
doi = "10.1016/j.febslet.2011.05.058",
language = "English",
volume = "585",
pages = "2291--2294",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "14",

}

RIS

TY - JOUR

T1 - Regucalcin (RGN/SMP30) alters agonist- and thapsigargin- induced cytosolic [Ca2+] transients in cells by increasing SERCA Ca(2+)ATPase levels

AU - Lai, P

AU - Yip, Nga

AU - Michelangeli, Francesco

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Regucalcin (RGN), also reported as senescence marker protein-30 (SMP30), plays a role in Ca2+ homeostasis by modulating a number of Ca2+-dependent proteins. RGN also plays a cyto-protective role and its decrease is linked to age-related diseases and cell death. This study shows that RGN reduces agonist (histamine)-induced Ca2+ transients in RGN(+) transfected COS-7 cells (RGN(+)) and also increases their Ca2+ storage capacity. These observations are explained by RGN(+) cells having increased mRNA and protein expression levels of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Therefore down-regulation of RGN expression may contribute to characteristics of age-dependent Ca2+ homeostasis dis-regulation, by decreasing SERCA levels. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

AB - Regucalcin (RGN), also reported as senescence marker protein-30 (SMP30), plays a role in Ca2+ homeostasis by modulating a number of Ca2+-dependent proteins. RGN also plays a cyto-protective role and its decrease is linked to age-related diseases and cell death. This study shows that RGN reduces agonist (histamine)-induced Ca2+ transients in RGN(+) transfected COS-7 cells (RGN(+)) and also increases their Ca2+ storage capacity. These observations are explained by RGN(+) cells having increased mRNA and protein expression levels of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Therefore down-regulation of RGN expression may contribute to characteristics of age-dependent Ca2+ homeostasis dis-regulation, by decreasing SERCA levels. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

KW - Calcium homeostasis

KW - Regucalcin

KW - Sarco/endo-plasmic reticulum Ca2+-ATPase

KW - Aging

KW - Senescence marker protein-30

U2 - 10.1016/j.febslet.2011.05.058

DO - 10.1016/j.febslet.2011.05.058

M3 - Article

C2 - 21684279

VL - 585

SP - 2291

EP - 2294

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 14

ER -