Regioselective functionalisation of dibenzothiophenes through gold-catalysed intermolecular alkyne oxyarylation
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
A protocol has been developed for direct Csp3-Csp2 bond formation at the 4- and 6-positions of dibenzothiophenes using a gold(I) catalyst with terminal alkynes and dibenzothiophene-S-oxides. The sulfoxide acts as a traceless directing group to avoid the need to prefunctionalise at carbon. The iterative use of this protocol is possible and has been employed in the preparation of novel macrocyclic structures. In addition, a cascade process shows how oxyarylations can be combined with other processes resulting in complex, highly efficient transformations.
|Number of pages||11|
|Journal||Organic and Biomolecular Chemistry|
|Early online date||7 Jul 2015|
|Publication status||Published - 28 Aug 2015|