Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease

Research output: Contribution to journalArticle

Standard

Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease. / Reilly, TJ; Staff, RT; Ahearn, TS; Bentham, Peter; Wischik, CM; Murray, AD.

In: Behavioural Brain Research, Vol. 222, No. 2, 01.09.2011, p. 375-379.

Research output: Contribution to journalArticle

Harvard

Reilly, TJ, Staff, RT, Ahearn, TS, Bentham, P, Wischik, CM & Murray, AD 2011, 'Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease', Behavioural Brain Research, vol. 222, no. 2, pp. 375-379. https://doi.org/10.1016/j.bbr.2011.04.003

APA

Reilly, TJ., Staff, RT., Ahearn, TS., Bentham, P., Wischik, CM., & Murray, AD. (2011). Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease. Behavioural Brain Research, 222(2), 375-379. https://doi.org/10.1016/j.bbr.2011.04.003

Vancouver

Author

Reilly, TJ ; Staff, RT ; Ahearn, TS ; Bentham, Peter ; Wischik, CM ; Murray, AD. / Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease. In: Behavioural Brain Research. 2011 ; Vol. 222, No. 2. pp. 375-379.

Bibtex

@article{f969a42da49d4622bf1e65574d4f2e02,
title = "Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease",
abstract = "Aberrant motor behaviour (AMB) in Alzheimer's disease shares behavioural correlates with obsessive compulsive disorder (OCD). We investigated whether AMB was also comparable in terms of metabolic activity in the orbitofrontal cortex (OFC), an area shown to be hyperactive in OCD. In this study 135 patients meeting research criteria for Alzheimer's disease were identified from a database of patients recruited as part of a phase II drug trial. These patients were assessed using the Neuropsychiatric Inventory, the Alzheimer's disease assessment scale, cognitive subscale and perfusion SPECT performed with Tc-99(m) hexamethylpropyleneamine oxime. Regions of interest were created for orbitofrontal cortices and basal ganglia. In 35 patients with AMB, adjusted tracer uptake was greater in the OFC. This reached statistical significance in right superior, left superior, right medial and left medial orbital gyri (p <0.05). The association between AMB and hyperactivity in the OFC remained significant after adjusting for the presence of anxiety. These results parallel the OFC hypermetabolism consistently seen in OCD. One model of OCD, proposes that dysfunctional interactions between frontal regions, including the OFC, produce the characteristic symptoms of OCD. The behaviour is though to be brought about by a perceived incompleteness of performing a task and is caused by an error in normal reward signals initiated upon task completion. These finding indicate that AMB in Alzheimer's disease are brought about by the same mechanistic failure. (C) 2011 Elsevier B.V. All rights reserved.",
keywords = "Technetium, SPECT, Alzheimer disease, Obsessive-compulsive disorder",
author = "TJ Reilly and RT Staff and TS Ahearn and Peter Bentham and CM Wischik and AD Murray",
year = "2011",
month = sep,
day = "1",
doi = "10.1016/j.bbr.2011.04.003",
language = "English",
volume = "222",
pages = "375--379",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease

AU - Reilly, TJ

AU - Staff, RT

AU - Ahearn, TS

AU - Bentham, Peter

AU - Wischik, CM

AU - Murray, AD

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Aberrant motor behaviour (AMB) in Alzheimer's disease shares behavioural correlates with obsessive compulsive disorder (OCD). We investigated whether AMB was also comparable in terms of metabolic activity in the orbitofrontal cortex (OFC), an area shown to be hyperactive in OCD. In this study 135 patients meeting research criteria for Alzheimer's disease were identified from a database of patients recruited as part of a phase II drug trial. These patients were assessed using the Neuropsychiatric Inventory, the Alzheimer's disease assessment scale, cognitive subscale and perfusion SPECT performed with Tc-99(m) hexamethylpropyleneamine oxime. Regions of interest were created for orbitofrontal cortices and basal ganglia. In 35 patients with AMB, adjusted tracer uptake was greater in the OFC. This reached statistical significance in right superior, left superior, right medial and left medial orbital gyri (p <0.05). The association between AMB and hyperactivity in the OFC remained significant after adjusting for the presence of anxiety. These results parallel the OFC hypermetabolism consistently seen in OCD. One model of OCD, proposes that dysfunctional interactions between frontal regions, including the OFC, produce the characteristic symptoms of OCD. The behaviour is though to be brought about by a perceived incompleteness of performing a task and is caused by an error in normal reward signals initiated upon task completion. These finding indicate that AMB in Alzheimer's disease are brought about by the same mechanistic failure. (C) 2011 Elsevier B.V. All rights reserved.

AB - Aberrant motor behaviour (AMB) in Alzheimer's disease shares behavioural correlates with obsessive compulsive disorder (OCD). We investigated whether AMB was also comparable in terms of metabolic activity in the orbitofrontal cortex (OFC), an area shown to be hyperactive in OCD. In this study 135 patients meeting research criteria for Alzheimer's disease were identified from a database of patients recruited as part of a phase II drug trial. These patients were assessed using the Neuropsychiatric Inventory, the Alzheimer's disease assessment scale, cognitive subscale and perfusion SPECT performed with Tc-99(m) hexamethylpropyleneamine oxime. Regions of interest were created for orbitofrontal cortices and basal ganglia. In 35 patients with AMB, adjusted tracer uptake was greater in the OFC. This reached statistical significance in right superior, left superior, right medial and left medial orbital gyri (p <0.05). The association between AMB and hyperactivity in the OFC remained significant after adjusting for the presence of anxiety. These results parallel the OFC hypermetabolism consistently seen in OCD. One model of OCD, proposes that dysfunctional interactions between frontal regions, including the OFC, produce the characteristic symptoms of OCD. The behaviour is though to be brought about by a perceived incompleteness of performing a task and is caused by an error in normal reward signals initiated upon task completion. These finding indicate that AMB in Alzheimer's disease are brought about by the same mechanistic failure. (C) 2011 Elsevier B.V. All rights reserved.

KW - Technetium

KW - SPECT

KW - Alzheimer disease

KW - Obsessive-compulsive disorder

U2 - 10.1016/j.bbr.2011.04.003

DO - 10.1016/j.bbr.2011.04.003

M3 - Article

C2 - 21507335

VL - 222

SP - 375

EP - 379

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -