Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone

Annette Spreer; Holger Kerstan; Tobias Böttcher; Joachim Gerber; Alexander Siemer; Gregor Zysk; Timothy J Mitchell; Helmut Eiffert; Roland Nau

Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone

Annette Spreer, Holger Kerstan, Tobias Böttcher, Joachim Gerber, Alexander Siemer, Gregor Zysk, Timothy J Mitchell, Helmut Eiffert, Roland Nau

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Pneumolysin, a virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities, occurs at concentrations from 0.85 to 180 ng/ml in cerebrospinal fluid (CSF) of meningitis patients. In pneumococcal cultures and in a rabbit meningitis model, the concentrations of pneumolysin in supernatant and CSF were lower after addition of nonbacteriolytic bactericidal antibiotics (rifampin and clindamycin) than after incubation with ceftriaxone.

Original language	English
Pages (from-to)	2649-54
Number of pages	6
Journal	Antimicrobial Agents and Chemotherapy
Volume	47
Issue number	8
Publication status	Published - Aug 2003

Keywords

Adult
Aged
Animals
Anti-Bacterial Agents
Bacterial Proteins
Ceftriaxone
Cephalosporins
Child, Preschool
Colony Count, Microbial
Culture Media
Depression, Chemical
Electrophoresis, Polyacrylamide Gel
Female
Humans
Male
Meningitis, Pneumococcal
Microbial Sensitivity Tests
Middle Aged
Rabbits
Streptococcus pneumoniae
Streptolysins

Cite this

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title = "Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone",

abstract = "Pneumolysin, a virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities, occurs at concentrations from 0.85 to 180 ng/ml in cerebrospinal fluid (CSF) of meningitis patients. In pneumococcal cultures and in a rabbit meningitis model, the concentrations of pneumolysin in supernatant and CSF were lower after addition of nonbacteriolytic bactericidal antibiotics (rifampin and clindamycin) than after incubation with ceftriaxone.",

keywords = "Adult, Aged, Animals, Anti-Bacterial Agents, Bacterial Proteins, Ceftriaxone, Cephalosporins, Child, Preschool, Colony Count, Microbial, Culture Media, Depression, Chemical, Electrophoresis, Polyacrylamide Gel, Female, Humans, Male, Meningitis, Pneumococcal, Microbial Sensitivity Tests, Middle Aged, Rabbits, Streptococcus pneumoniae, Streptolysins",

author = "Annette Spreer and Holger Kerstan and Tobias B{\"o}ttcher and Joachim Gerber and Alexander Siemer and Gregor Zysk and Mitchell, {Timothy J} and Helmut Eiffert and Roland Nau",

year = "2003",

month = aug,

language = "English",

volume = "47",

pages = "2649--54",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "8",

}

TY - JOUR

T1 - Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone

AU - Spreer, Annette

AU - Kerstan, Holger

AU - Böttcher, Tobias

AU - Gerber, Joachim

AU - Siemer, Alexander

AU - Zysk, Gregor

AU - Mitchell, Timothy J

AU - Eiffert, Helmut

AU - Nau, Roland

PY - 2003/8

Y1 - 2003/8

N2 - Pneumolysin, a virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities, occurs at concentrations from 0.85 to 180 ng/ml in cerebrospinal fluid (CSF) of meningitis patients. In pneumococcal cultures and in a rabbit meningitis model, the concentrations of pneumolysin in supernatant and CSF were lower after addition of nonbacteriolytic bactericidal antibiotics (rifampin and clindamycin) than after incubation with ceftriaxone.

AB - Pneumolysin, a virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities, occurs at concentrations from 0.85 to 180 ng/ml in cerebrospinal fluid (CSF) of meningitis patients. In pneumococcal cultures and in a rabbit meningitis model, the concentrations of pneumolysin in supernatant and CSF were lower after addition of nonbacteriolytic bactericidal antibiotics (rifampin and clindamycin) than after incubation with ceftriaxone.

KW - Adult

KW - Aged

KW - Animals

KW - Anti-Bacterial Agents

KW - Bacterial Proteins

KW - Ceftriaxone

KW - Cephalosporins

KW - Child, Preschool

KW - Colony Count, Microbial

KW - Culture Media

KW - Depression, Chemical

KW - Electrophoresis, Polyacrylamide Gel

KW - Female

KW - Humans

KW - Male

KW - Meningitis, Pneumococcal

KW - Microbial Sensitivity Tests

KW - Middle Aged

KW - Rabbits

KW - Streptococcus pneumoniae

KW - Streptolysins

M3 - Article

C2 - 12878534

SN - 0066-4804

VL - 47

SP - 2649

EP - 2654

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone

Abstract

Keywords

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