Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress

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@article{8ab65f64aa8940a3b8a3478431039afc,
title = "Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress",
abstract = "Ageing is associated with higher morbidity and mortality, and declining immune function, termed immunesenescence. The present study examined the effects of an acute laboratory psychological stress task on innate immunity, specifically neutrophil function, among older adults. The two functional assays used were phagocytosis of Escherichia coli and stimulated superoxide production. Participants were 17 (11 female) older adults (mean age 75.7, SD=7.06 years). Blood samples to determine neutrophil function by flow cytometry were taken at the end of resting baseline, during an acute stress task and during recovery. The stress task was an 8-minute time-pressured mental arithmetic challenge with social evaluation. There was a significant reduction in neutrophil superoxide production, p=.017, η(2)(p)=.240, associated with the stress task relative to baseline, but no effect on phagocytosis. The results of this study could contribute to explaining the increased risk of infection in older adults, particularly those subject to frequent stress exposures. Future research is needed to explore the underlying mechanisms of acute stress effects on human neutrophil function in older adults in greater detail.",
keywords = "Aged, Aged, 80 and over, Aging, Analysis of Variance, Blood Pressure, Dehydroepiandrosterone, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Heart Rate, Humans, Hydrocortisone, Lymphocytes, Male, Mental Status Schedule, Neutrophils, Phagocytosis, Questionnaires, Stress, Psychological, Superoxides, Time Factors",
author = "{Suliman Khanfer}, Riyad and Janet Lord and Douglas Carroll and Anna Phillips",
year = "2012",
month = dec
doi = "10.1016/j.ijpsycho.2012.09.013",
language = "English",
volume = "86",
pages = "238--244",
journal = "International journal of psychophysiology : official journal of the International Organization of Psychophysiology",
issn = "0167-8760",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress

AU - Suliman Khanfer, Riyad

AU - Lord, Janet

AU - Carroll, Douglas

AU - Phillips, Anna

PY - 2012/12

Y1 - 2012/12

N2 - Ageing is associated with higher morbidity and mortality, and declining immune function, termed immunesenescence. The present study examined the effects of an acute laboratory psychological stress task on innate immunity, specifically neutrophil function, among older adults. The two functional assays used were phagocytosis of Escherichia coli and stimulated superoxide production. Participants were 17 (11 female) older adults (mean age 75.7, SD=7.06 years). Blood samples to determine neutrophil function by flow cytometry were taken at the end of resting baseline, during an acute stress task and during recovery. The stress task was an 8-minute time-pressured mental arithmetic challenge with social evaluation. There was a significant reduction in neutrophil superoxide production, p=.017, η(2)(p)=.240, associated with the stress task relative to baseline, but no effect on phagocytosis. The results of this study could contribute to explaining the increased risk of infection in older adults, particularly those subject to frequent stress exposures. Future research is needed to explore the underlying mechanisms of acute stress effects on human neutrophil function in older adults in greater detail.

AB - Ageing is associated with higher morbidity and mortality, and declining immune function, termed immunesenescence. The present study examined the effects of an acute laboratory psychological stress task on innate immunity, specifically neutrophil function, among older adults. The two functional assays used were phagocytosis of Escherichia coli and stimulated superoxide production. Participants were 17 (11 female) older adults (mean age 75.7, SD=7.06 years). Blood samples to determine neutrophil function by flow cytometry were taken at the end of resting baseline, during an acute stress task and during recovery. The stress task was an 8-minute time-pressured mental arithmetic challenge with social evaluation. There was a significant reduction in neutrophil superoxide production, p=.017, η(2)(p)=.240, associated with the stress task relative to baseline, but no effect on phagocytosis. The results of this study could contribute to explaining the increased risk of infection in older adults, particularly those subject to frequent stress exposures. Future research is needed to explore the underlying mechanisms of acute stress effects on human neutrophil function in older adults in greater detail.

KW - Aged

KW - Aged, 80 and over

KW - Aging

KW - Analysis of Variance

KW - Blood Pressure

KW - Dehydroepiandrosterone

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Flow Cytometry

KW - Heart Rate

KW - Humans

KW - Hydrocortisone

KW - Lymphocytes

KW - Male

KW - Mental Status Schedule

KW - Neutrophils

KW - Phagocytosis

KW - Questionnaires

KW - Stress, Psychological

KW - Superoxides

KW - Time Factors

U2 - 10.1016/j.ijpsycho.2012.09.013

DO - 10.1016/j.ijpsycho.2012.09.013

M3 - Article

C2 - 23041234

VL - 86

SP - 238

EP - 244

JO - International journal of psychophysiology : official journal of the International Organization of Psychophysiology

JF - International journal of psychophysiology : official journal of the International Organization of Psychophysiology

SN - 0167-8760

IS - 3

ER -