Red blood cell nitric oxide as an endocrine vasoregulator: a potential role in congestive heart failure

B Datta, T Tufnell-Barret, RA Bleasdale, CJ Jones, I Beeton, V Paul, Michael Frenneaux, P James

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

BACKGROUND: A respiratory cycle for nitric oxide (NO) would involve the formation of vasoactive metabolites between NO and hemoglobin during pulmonary oxygenation. We investigated the role of these metabolites in hypoxic tissue in vitro and in vivo in healthy subjects and patients with congestive heart failure (CHF). METHODS AND RESULTS: We investigated the capacity for red blood cells (RBCs) to dilate preconstricted aortic rings under various O2 tensions. RBCs induced cyclic guanylyl monophosphate-dependent vasorelaxation during hypoxia (35+/-4% at 1% O2, 4.7+/-1.6% at 95% O2; P
Original languageEnglish
Pages (from-to)1339-1342
Number of pages4
JournalCirculation
Volume109
DOIs
Publication statusPublished - 1 Jan 2004

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