Recyclable L-Proline Functional Nanoreactors with Temperature-Tuned Activity Based on Core-Shell Nanogels

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Recyclable L-Proline Functional Nanoreactors with Temperature-Tuned Activity Based on Core-Shell Nanogels. / Lu, Annhelen; Moatsou, Dafni; Hands-Portman, Ian; Longbottom, Deborah A.; O'Reilly, Rachel K.

In: ACS Macro Letters, Vol. 3, No. 12, 16.12.2014, p. 1235-1239.

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Lu, Annhelen ; Moatsou, Dafni ; Hands-Portman, Ian ; Longbottom, Deborah A. ; O'Reilly, Rachel K. / Recyclable L-Proline Functional Nanoreactors with Temperature-Tuned Activity Based on Core-Shell Nanogels. In: ACS Macro Letters. 2014 ; Vol. 3, No. 12. pp. 1235-1239.

Bibtex

@article{db356fbe22e74b01bc5372a070dcacf7,
title = "Recyclable L-Proline Functional Nanoreactors with Temperature-Tuned Activity Based on Core-Shell Nanogels",
abstract = "Recyclable core–shell (CS) nanogels based on l-proline-containing hydrophobic cores with a thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) shell have been synthesized via a seeded precipitation polymerization process. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) were used to verify the successful addition of the shell and investigate the thermoresponsive properties of the nanostructures. The catalytic activity of the nanogels was assessed in a model asymmetric aldol reaction, where an enhancement was observed with increasing temperature, attributed to the hydrophobic nature of the PNIPAM shell. However, when a nanogel was synthesized with core–shell morphology based on a gradient of cross-linking density in the corona (GS), a dramatic drop in activity was observed at elevated temperatures: the collapse of the outer, lightly cross-linked, “corona” polymer chains appears to block access to the catalytic core. High activity and enantioselectivity were maintained in a number of recovery and reuse cycles, highlighting the recycling potential of these catalytic nanostructures.",
author = "Annhelen Lu and Dafni Moatsou and Ian Hands-Portman and Longbottom, {Deborah A.} and O'Reilly, {Rachel K.}",
year = "2014",
month = dec,
day = "16",
doi = "10.1021/mz500704y",
language = "English",
volume = "3",
pages = "1235--1239",
journal = "ACS Macro Letters",
issn = "2161-1653",
publisher = "American Chemical Society",
number = "12",

}

RIS

TY - JOUR

T1 - Recyclable L-Proline Functional Nanoreactors with Temperature-Tuned Activity Based on Core-Shell Nanogels

AU - Lu, Annhelen

AU - Moatsou, Dafni

AU - Hands-Portman, Ian

AU - Longbottom, Deborah A.

AU - O'Reilly, Rachel K.

PY - 2014/12/16

Y1 - 2014/12/16

N2 - Recyclable core–shell (CS) nanogels based on l-proline-containing hydrophobic cores with a thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) shell have been synthesized via a seeded precipitation polymerization process. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) were used to verify the successful addition of the shell and investigate the thermoresponsive properties of the nanostructures. The catalytic activity of the nanogels was assessed in a model asymmetric aldol reaction, where an enhancement was observed with increasing temperature, attributed to the hydrophobic nature of the PNIPAM shell. However, when a nanogel was synthesized with core–shell morphology based on a gradient of cross-linking density in the corona (GS), a dramatic drop in activity was observed at elevated temperatures: the collapse of the outer, lightly cross-linked, “corona” polymer chains appears to block access to the catalytic core. High activity and enantioselectivity were maintained in a number of recovery and reuse cycles, highlighting the recycling potential of these catalytic nanostructures.

AB - Recyclable core–shell (CS) nanogels based on l-proline-containing hydrophobic cores with a thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) shell have been synthesized via a seeded precipitation polymerization process. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) were used to verify the successful addition of the shell and investigate the thermoresponsive properties of the nanostructures. The catalytic activity of the nanogels was assessed in a model asymmetric aldol reaction, where an enhancement was observed with increasing temperature, attributed to the hydrophobic nature of the PNIPAM shell. However, when a nanogel was synthesized with core–shell morphology based on a gradient of cross-linking density in the corona (GS), a dramatic drop in activity was observed at elevated temperatures: the collapse of the outer, lightly cross-linked, “corona” polymer chains appears to block access to the catalytic core. High activity and enantioselectivity were maintained in a number of recovery and reuse cycles, highlighting the recycling potential of these catalytic nanostructures.

UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000346681800004&KeyUID=WOS:000346681800004

U2 - 10.1021/mz500704y

DO - 10.1021/mz500704y

M3 - Letter

VL - 3

SP - 1235

EP - 1239

JO - ACS Macro Letters

JF - ACS Macro Letters

SN - 2161-1653

IS - 12

ER -