Recruitment of RNA polymerase to Class II CRP-dependent promoters is improved by a second upstream-bound CRP molecule

Nora Miroslavova; Jennie Mitchell; J Tebbutt; Stephen Busby

doi:10.1042/BST0341075

Recruitment of RNA polymerase to Class II CRP-dependent promoters is improved by a second upstream-bound CRP molecule

Nora Miroslavova, Jennie Mitchell, J Tebbutt, Stephen Busby

Biosciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Genetics and biochemistry have been exploited to investigate transcription activation by the Escherichia coli CRP (cAMP receptor protein) factor at promoters with a DNA site for CRP near position -41 and the effects of a second upstream-bound CRP molecule. We show that the upstream-bound CRP contributes to transcription activation by improving the recruitment of RNA polymerase.

Original language	English
Pages (from-to)	1075-1078
Number of pages	4
Journal	Biochemical Society Transactions
Volume	34
Issue number	6
DOIs	https://doi.org/10.1042/BST0341075
Publication status	Published - 1 Dec 2006

Keywords

cAMP receptor protein (CRP)
RNA polymerase
recruitment
activation of transcription
kinetic analysis
transcription

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10.1042/BST0341075

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abstract = "Genetics and biochemistry have been exploited to investigate transcription activation by the Escherichia coli CRP (cAMP receptor protein) factor at promoters with a DNA site for CRP near position -41 and the effects of a second upstream-bound CRP molecule. We show that the upstream-bound CRP contributes to transcription activation by improving the recruitment of RNA polymerase.",

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AU - Tebbutt, J

AU - Busby, Stephen

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AB - Genetics and biochemistry have been exploited to investigate transcription activation by the Escherichia coli CRP (cAMP receptor protein) factor at promoters with a DNA site for CRP near position -41 and the effects of a second upstream-bound CRP molecule. We show that the upstream-bound CRP contributes to transcription activation by improving the recruitment of RNA polymerase.

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KW - RNA polymerase

KW - recruitment

KW - activation of transcription

KW - kinetic analysis

KW - transcription

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JO - Biochemical Society Transactions

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Recruitment of RNA polymerase to Class II CRP-dependent promoters is improved by a second upstream-bound CRP molecule

Abstract

Keywords

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