Recruitment of RNA polymerase to Class II CRP-dependent promoters is improved by a second upstream-bound CRP molecule

Research output: Contribution to journalArticlepeer-review

Colleges, School and Institutes


Genetics and biochemistry have been exploited to investigate transcription activation by the Escherichia coli CRP (cAMP receptor protein) factor at promoters with a DNA site for CRP near position -41 and the effects of a second upstream-bound CRP molecule. We show that the upstream-bound CRP contributes to transcription activation by improving the recruitment of RNA polymerase.


Original languageEnglish
Pages (from-to)1075-1078
Number of pages4
JournalBiochemical Society Transactions
Issue number6
Publication statusPublished - 1 Dec 2006


  • cAMP receptor protein (CRP), RNA polymerase, recruitment, activation of transcription, kinetic analysis, transcription