Abstract
We have investigated the neurochemical mechanisms of memory reconsolidation and, in particular, the functional requirement for intracellular mechanisms initiated by beta-adrenergic signaling. We show that propranolol, given in conjunction with a memory reactivation session, can specifically disrupt the conditioned reinforcing properties of a previously appetitively reinforced conditioned stimulus (CS), whether the stimulus had been associated with self-administered cocaine or with sucrose. These data show that memories for both drug and nondrug CS-US associations are dependent on beta-adrenergic receptor-mediated signaling for their reconsolidation, with implications for the potential development of a novel treatment for drug addiction and some forms of obesity.
| Original language | English |
|---|---|
| Pages (from-to) | 88-92 |
| Number of pages | 5 |
| Journal | Learning & memory |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Jan 2008 |
Access to Document
- Milton_2008_Learning_&_Memory
Copyright Cold Spring Harbor Laboratory Press. Citation for published version (Harvard): Milton, AL, Lee, J & Everitt, BJ 2008, 'Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on B-adrenergic receptors' Learning & Memory, vol 15, no. 2, pp. 88-92.