Reconsolidation of a well-learned instrumental memory

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Reconsolidation of a well-learned instrumental memory. / Exton-McGuinness, Marc T J; Patton, Rosemary C; Sacco, Lawrence B; Lee, Jonathan L C.

In: Learning & memory, Vol. 21, No. 9, 09.2014, p. 468-77.

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Exton-McGuinness, Marc T J ; Patton, Rosemary C ; Sacco, Lawrence B ; Lee, Jonathan L C. / Reconsolidation of a well-learned instrumental memory. In: Learning & memory. 2014 ; Vol. 21, No. 9. pp. 468-77.

Bibtex

@article{ebfe475e55864f4590e4c201003ef4a5,
title = "Reconsolidation of a well-learned instrumental memory",
abstract = "Once consolidated, memories are dynamic entities that go through phases of instability in order to be updated with new information, via a process of reconsolidation. The phenomenon of reconsolidation has been demonstrated in a wide variety of experimental paradigms. However, the memories underpinning instrumental behaviors are currently not believed to reconsolidate. We show that well-learned lever pressing in rats does undergo reconsolidation, which can be disrupted by systemic administration of the noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist (+)-5-methyl-10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) when administered prior to a switch to a variable, but not fixed, ratio schedule. Disruption of reconsolidation resulted in a reduction in long-term lever pressing performance and diminished the sensitivity of behavior to contingency change. Further investigation demonstrated that expression of the reconsolidation impairment was not affected by outcome value, implying a deficit in a stimulus-response (S-R) process. The ability to disrupt the performance of well-learned instrumental behaviors is potentially of great importance in the development of reconsolidation-based clinical treatments for conditions that involve compulsive seeking behaviors.",
author = "Exton-McGuinness, {Marc T J} and Patton, {Rosemary C} and Sacco, {Lawrence B} and Lee, {Jonathan L C}",
year = "2014",
month = sep,
doi = "10.1101/lm.035543.114",
language = "English",
volume = "21",
pages = "468--77",
journal = "Learning & memory",
issn = "1549-5485",
publisher = "Cold Spring Harbor Laboratory Press",
number = "9",

}

RIS

TY - JOUR

T1 - Reconsolidation of a well-learned instrumental memory

AU - Exton-McGuinness, Marc T J

AU - Patton, Rosemary C

AU - Sacco, Lawrence B

AU - Lee, Jonathan L C

PY - 2014/9

Y1 - 2014/9

N2 - Once consolidated, memories are dynamic entities that go through phases of instability in order to be updated with new information, via a process of reconsolidation. The phenomenon of reconsolidation has been demonstrated in a wide variety of experimental paradigms. However, the memories underpinning instrumental behaviors are currently not believed to reconsolidate. We show that well-learned lever pressing in rats does undergo reconsolidation, which can be disrupted by systemic administration of the noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist (+)-5-methyl-10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) when administered prior to a switch to a variable, but not fixed, ratio schedule. Disruption of reconsolidation resulted in a reduction in long-term lever pressing performance and diminished the sensitivity of behavior to contingency change. Further investigation demonstrated that expression of the reconsolidation impairment was not affected by outcome value, implying a deficit in a stimulus-response (S-R) process. The ability to disrupt the performance of well-learned instrumental behaviors is potentially of great importance in the development of reconsolidation-based clinical treatments for conditions that involve compulsive seeking behaviors.

AB - Once consolidated, memories are dynamic entities that go through phases of instability in order to be updated with new information, via a process of reconsolidation. The phenomenon of reconsolidation has been demonstrated in a wide variety of experimental paradigms. However, the memories underpinning instrumental behaviors are currently not believed to reconsolidate. We show that well-learned lever pressing in rats does undergo reconsolidation, which can be disrupted by systemic administration of the noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist (+)-5-methyl-10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) when administered prior to a switch to a variable, but not fixed, ratio schedule. Disruption of reconsolidation resulted in a reduction in long-term lever pressing performance and diminished the sensitivity of behavior to contingency change. Further investigation demonstrated that expression of the reconsolidation impairment was not affected by outcome value, implying a deficit in a stimulus-response (S-R) process. The ability to disrupt the performance of well-learned instrumental behaviors is potentially of great importance in the development of reconsolidation-based clinical treatments for conditions that involve compulsive seeking behaviors.

U2 - 10.1101/lm.035543.114

DO - 10.1101/lm.035543.114

M3 - Article

C2 - 25135195

VL - 21

SP - 468

EP - 477

JO - Learning & memory

JF - Learning & memory

SN - 1549-5485

IS - 9

ER -