Recombinant protein production in bacterial hosts.

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

Abstract

The production of recombinant proteins is crucial for both the development of new protein drugs and the structural determination of drug targets. As such, recombinant protein production has a major role in drug development. Bacterial hosts are commonly used for the production of recombinant proteins, accounting for approximately 30% of current biopharmaceuticals on the market. In this review, I introduce fundamental concepts in recombinant protein production in bacteria, from drug development to production scales. Recombinant protein production processes can often fail, but how can this failure be minimised to rapidly deliver maximum yields of high-quality protein and so accelerate drug discovery?

Details

Original languageEnglish
Pages (from-to)590-601
JournalDrug Discovery Today
Volume19
Issue number5
Early online date15 Nov 2013
Publication statusPublished - 1 Jun 2014