Recognition-Mediated Regiocontrol of a Dipolar Cycloaddition Reaction

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Recognition-Mediated Regiocontrol of a Dipolar Cycloaddition Reaction. / Howell, SJ; Spencer, Neil; Philp, Douglas.

In: Tetrahedron, Vol. 57, No. 23, 04.06.2001, p. 4945-4954.

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Howell, SJ ; Spencer, Neil ; Philp, Douglas. / Recognition-Mediated Regiocontrol of a Dipolar Cycloaddition Reaction. In: Tetrahedron. 2001 ; Vol. 57, No. 23. pp. 4945-4954.

Bibtex

@article{734bde1079f74437a3b177d32f2670c6,
title = "Recognition-Mediated Regiocontrol of a Dipolar Cycloaddition Reaction",
abstract = "The rational design of a recognition-based system that is capable of accelerating and controlling the regiochemical outcome of a dipolar cycloaddition reaction between an azide and an alkyne is presented. The origins of the acceleration and control of the cycloaddition reactions are rationalized-using molecular mechanics calculations-in terms of the formation of a complex between the reagents which organizes and orients them prior to reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.",
keywords = "cycloaddition, molecular recognition, azides, kinetics",
author = "SJ Howell and Neil Spencer and Douglas Philp",
year = "2001",
month = jun,
day = "4",
doi = "10.1016/S0040-4020(01)00402-1",
language = "English",
volume = "57",
pages = "4945--4954",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier",
number = "23",

}

RIS

TY - JOUR

T1 - Recognition-Mediated Regiocontrol of a Dipolar Cycloaddition Reaction

AU - Howell, SJ

AU - Spencer, Neil

AU - Philp, Douglas

PY - 2001/6/4

Y1 - 2001/6/4

N2 - The rational design of a recognition-based system that is capable of accelerating and controlling the regiochemical outcome of a dipolar cycloaddition reaction between an azide and an alkyne is presented. The origins of the acceleration and control of the cycloaddition reactions are rationalized-using molecular mechanics calculations-in terms of the formation of a complex between the reagents which organizes and orients them prior to reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

AB - The rational design of a recognition-based system that is capable of accelerating and controlling the regiochemical outcome of a dipolar cycloaddition reaction between an azide and an alkyne is presented. The origins of the acceleration and control of the cycloaddition reactions are rationalized-using molecular mechanics calculations-in terms of the formation of a complex between the reagents which organizes and orients them prior to reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

KW - cycloaddition

KW - molecular recognition

KW - azides

KW - kinetics

UR - http://www.scopus.com/inward/record.url?scp=0035806175&partnerID=8YFLogxK

U2 - 10.1016/S0040-4020(01)00402-1

DO - 10.1016/S0040-4020(01)00402-1

M3 - Article

VL - 57

SP - 4945

EP - 4954

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 23

ER -