Abstract
The rational design of a recognition-based system that is capable of accelerating and controlling the regiochemical outcome of a dipolar cycloaddition reaction between an azide and an alkyne is presented. The origins of the acceleration and control of the cycloaddition reactions are rationalized-using molecular mechanics calculations-in terms of the formation of a complex between the reagents which organizes and orients them prior to reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 4945-4954 |
| Number of pages | 10 |
| Journal | Tetrahedron |
| Volume | 57 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 4 Jun 2001 |
Keywords
- cycloaddition
- molecular recognition
- azides
- kinetics