Recognition-Mediated Regiocontrol of a Dipolar Cycloaddition Reaction
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Colleges, School and Institutes
The rational design of a recognition-based system that is capable of accelerating and controlling the regiochemical outcome of a dipolar cycloaddition reaction between an azide and an alkyne is presented. The origins of the acceleration and control of the cycloaddition reactions are rationalized-using molecular mechanics calculations-in terms of the formation of a complex between the reagents which organizes and orients them prior to reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.
|Number of pages||10|
|Publication status||Published - 4 Jun 2001|
- cycloaddition, molecular recognition, azides, kinetics