Recent studies implicate the nucleolus as the major site of nuclear translation

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Recent studies implicate the nucleolus as the major site of nuclear translation. / McLeod, Tina; Abdullahi, Akilu; Li, Min; Brogna, Saverio.

In: Biochemical Society Transactions, Vol. 42, No. 4, 11.08.2014, p. 1224-1228.

Research output: Contribution to journalConference article

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McLeod, Tina ; Abdullahi, Akilu ; Li, Min ; Brogna, Saverio. / Recent studies implicate the nucleolus as the major site of nuclear translation. In: Biochemical Society Transactions. 2014 ; Vol. 42, No. 4. pp. 1224-1228.

Bibtex

@article{d94d560e48544366a844375df6e799c5,
title = "Recent studies implicate the nucleolus as the major site of nuclear translation",
abstract = "The nucleolus is the most prominent morphological feature within the nucleus of eukaryotic cells and is best known for its role in ribosome biogenesis. It forms around highly transcribed ribosomal RNA gene repeats which yield precursor rRNAs that are co-transcriptionally processed, folded and, while still within the nucleolus, associate with most of the ribosomal proteins. The nucleolus is therefore often thought of as a factory for making ribosomal subunits, which are exported as inactive precursors to the cytoplasm where late maturation makes them capable of mRNA binding and translation initiation. However, recent studies have shown substantial evidence for the presence of functional, translation competent ribosomal subunits within the nucleus, particularly in the nucleolus. These observations raise the intriguing possibility that the nucleolus, as well as being a ribosome factory, is also an important nuclear protein-synthesis plant.",
keywords = "Animals, Cell Nucleolus, Cell Nucleus, Humans, Ribosomal Proteins, Ribosome Subunits, Ribosomes, nuclear translation, NMD, nucleolus, ribosome biogenesis",
author = "Tina McLeod and Akilu Abdullahi and Min Li and Saverio Brogna",
year = "2014",
month = aug,
day = "11",
doi = "10.1042/BST20140062",
language = "English",
volume = "42",
pages = "1224--1228",
journal = "Biochemical Society Transactions",
issn = "1470-8752",
publisher = "Portland Press",
number = "4",

}

RIS

TY - JOUR

T1 - Recent studies implicate the nucleolus as the major site of nuclear translation

AU - McLeod, Tina

AU - Abdullahi, Akilu

AU - Li, Min

AU - Brogna, Saverio

PY - 2014/8/11

Y1 - 2014/8/11

N2 - The nucleolus is the most prominent morphological feature within the nucleus of eukaryotic cells and is best known for its role in ribosome biogenesis. It forms around highly transcribed ribosomal RNA gene repeats which yield precursor rRNAs that are co-transcriptionally processed, folded and, while still within the nucleolus, associate with most of the ribosomal proteins. The nucleolus is therefore often thought of as a factory for making ribosomal subunits, which are exported as inactive precursors to the cytoplasm where late maturation makes them capable of mRNA binding and translation initiation. However, recent studies have shown substantial evidence for the presence of functional, translation competent ribosomal subunits within the nucleus, particularly in the nucleolus. These observations raise the intriguing possibility that the nucleolus, as well as being a ribosome factory, is also an important nuclear protein-synthesis plant.

AB - The nucleolus is the most prominent morphological feature within the nucleus of eukaryotic cells and is best known for its role in ribosome biogenesis. It forms around highly transcribed ribosomal RNA gene repeats which yield precursor rRNAs that are co-transcriptionally processed, folded and, while still within the nucleolus, associate with most of the ribosomal proteins. The nucleolus is therefore often thought of as a factory for making ribosomal subunits, which are exported as inactive precursors to the cytoplasm where late maturation makes them capable of mRNA binding and translation initiation. However, recent studies have shown substantial evidence for the presence of functional, translation competent ribosomal subunits within the nucleus, particularly in the nucleolus. These observations raise the intriguing possibility that the nucleolus, as well as being a ribosome factory, is also an important nuclear protein-synthesis plant.

KW - Animals

KW - Cell Nucleolus

KW - Cell Nucleus

KW - Humans

KW - Ribosomal Proteins

KW - Ribosome Subunits

KW - Ribosomes

KW - nuclear translation

KW - NMD

KW - nucleolus

KW - ribosome biogenesis

U2 - 10.1042/BST20140062

DO - 10.1042/BST20140062

M3 - Conference article

C2 - 25110029

VL - 42

SP - 1224

EP - 1228

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 1470-8752

IS - 4

ER -