Recent advances in the use of chiral metal complexes with achiral ligands for application in asymmetric catalysis

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Colleges, School and Institutes

External organisations

  • Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai
  • East China Normal University


This perspective describes recent progress in asymmetric catalysis with chiral only-at-metal complexes displaying Λ/Δ enantiomorphs in the absence of central chirality within the ligands, with an emphasis on Ir(III) and Rh(III) systems. The good selectivity achieved when using these complexes in asymmetric catalysis has been demonstrated in asymmetric transformations through various mechanisms, including hydrogen-bond donor–acceptor, secondary amine or Brønsted base hydrogen-bond donor bifunctional catalysis, Lewis acid and photoredox catalysis under mild reaction conditions. This perspective highlights the widening field of chiral-at-metal catalysis and presents a selection of asymmetric transformations which have been successfully carried out using them.


Original languageEnglish
Pages (from-to)3441-3451
Number of pages11
JournalCatalysis Science and Technology
Issue number7
Early online date6 Mar 2015
Publication statusPublished - Jul 2015

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