Recent advances in designed coiled coils and helical bundles with inorganic prosthetic groups - from structural to functional applications

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Colleges, School and Institutes


Recent contributions to the de novo design of metalloproteins based on coiled coils and helical bundles are described herein, with examples covering mononuclear, multinuclear, and metallo-porphyrin sites, as well as membrane soluble designs. Important progress is being made in the field with a diverse range of functionalities, sometimes beyond those found in biology, being successfully engineered into these simplified scaffolds and represents an exciting prospect for the future.


Original languageEnglish
Pages (from-to)160-165
Number of pages6
JournalCurrent Opinion in Chemical Biology
Early online date28 Mar 2016
Publication statusPublished - 1 Apr 2016

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