Recent advances in designed coiled coils and helical bundles with inorganic prosthetic groups - from structural to functional applications

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

Abstract

Recent contributions to the de novo design of metalloproteins based on coiled coils and helical bundles are described herein, with examples covering mononuclear, multinuclear, and metallo-porphyrin sites, as well as membrane soluble designs. Important progress is being made in the field with a diverse range of functionalities, sometimes beyond those found in biology, being successfully engineered into these simplified scaffolds and represents an exciting prospect for the future.

Details

Original languageEnglish
Pages (from-to)160-165
Number of pages6
JournalCurrent Opinion in Chemical Biology
Volume31
Early online date28 Mar 2016
Publication statusPublished - 1 Apr 2016

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