Recent advances in alkylidene carbene chemistry

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Recent advances in alkylidene carbene chemistry. / Grainger, Richard; Munro, Kevin.

In: Tetrahedron, Vol. 71, No. 41, 14.10.2015, p. 7795–7835.

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Grainger, Richard ; Munro, Kevin. / Recent advances in alkylidene carbene chemistry. In: Tetrahedron. 2015 ; Vol. 71, No. 41. pp. 7795–7835.

Bibtex

@article{2d66eb7ffa7c47d6999eb758e2392f4b,
title = "Recent advances in alkylidene carbene chemistry",
abstract = "Alkylidene carbenes, also called alkenylidenes, are reactive intermediates in organic chemistry. Despite their high reactivity, they undergo a range of synthetically useful transformations, including highly chemo- and regioselective intramolecular 1,5 insertions into unfunctionalized C-H bonds with retention of absolute configuration. This review article covers current understanding of the structure and bonding of alkylidene carbenes, methods of generation including recent analogous chemistry displayed by metal vinylidenes, the various factors affecting chemo-, regio- and diastereoselectivity, and applications in target synthesis.",
keywords = "Alkylidene carbene, Alkenylidene, Metal vinylidene, C–H insertion, Hypervalent iodine",
author = "Richard Grainger and Kevin Munro",
year = "2015",
month = oct
day = "14",
doi = "10.1016/j.tet.2015.06.053",
language = "English",
volume = "71",
pages = "7795–7835",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier",
number = "41",

}

RIS

TY - JOUR

T1 - Recent advances in alkylidene carbene chemistry

AU - Grainger, Richard

AU - Munro, Kevin

PY - 2015/10/14

Y1 - 2015/10/14

N2 - Alkylidene carbenes, also called alkenylidenes, are reactive intermediates in organic chemistry. Despite their high reactivity, they undergo a range of synthetically useful transformations, including highly chemo- and regioselective intramolecular 1,5 insertions into unfunctionalized C-H bonds with retention of absolute configuration. This review article covers current understanding of the structure and bonding of alkylidene carbenes, methods of generation including recent analogous chemistry displayed by metal vinylidenes, the various factors affecting chemo-, regio- and diastereoselectivity, and applications in target synthesis.

AB - Alkylidene carbenes, also called alkenylidenes, are reactive intermediates in organic chemistry. Despite their high reactivity, they undergo a range of synthetically useful transformations, including highly chemo- and regioselective intramolecular 1,5 insertions into unfunctionalized C-H bonds with retention of absolute configuration. This review article covers current understanding of the structure and bonding of alkylidene carbenes, methods of generation including recent analogous chemistry displayed by metal vinylidenes, the various factors affecting chemo-, regio- and diastereoselectivity, and applications in target synthesis.

KW - Alkylidene carbene

KW - Alkenylidene

KW - Metal vinylidene

KW - C–H insertion

KW - Hypervalent iodine

U2 - 10.1016/j.tet.2015.06.053

DO - 10.1016/j.tet.2015.06.053

M3 - Article

VL - 71

SP - 7795

EP - 7835

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 41

ER -