Real-time Cherenkov emission portal imaging during CyberKnife® radiotherapy

Research output: Contribution to journalArticle

Authors

  • Yiannis Roussakis
  • Rongxiao Zhang
  • Geoff Heyes
  • Gareth Webster
  • Suzannah Mason
  • Stuart Green
  • Brian Pogue

Colleges, School and Institutes

External organisations

  • Department of Physics and Astronomy, Dartmouth College
  • Medical Physics, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Birmingham
  • Medical Physics, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Birmingham
  • Thayer School of Engineering, Dartmouth College, NH03755, USA

Abstract

The feasibility of real-time portal imaging during radiation therapy, through the Cherenkov emission (CE) effect is investigated via a medical linear accelerator (CyberKnife®) irradiating a partially-filled water tank with a 60 mm circular beam. A graticule of lead/plywood and a number of tissue equivalent materials were alternatively placed at the beam entrance face while the induced CE at the exit face was imaged using a gated electron-multiplying-intensified-charged-coupled device (emICCD) for both stationary and dynamic scenarios. This was replicated on an Elekta Synergy® linear accelerator with portal images acquired using the iViewGT™ system. Profiles across the acquired portal images were analysed to reveal the potential resolution and contrast limits of this novel CE based portal imaging technique and compared against the current standard. The CE resolution study revealed that using the lead/plywood graticule, separations down to 3.4  ±  0.5 mm can be resolved. A 28 mm thick tissue-equivalent rod with electron density of 1.69 relative to water demonstrated a CE contrast of 15% through air and 14% through water sections, as compared to a corresponding contrast of 19% and 12% using the iViewGT™ system. For dynamic scenarios, video rate imaging with 30 frames per second was achieved. It is demonstrated that CE-based portal imaging is feasible to identify both stationary and dynamic objects within a CyberKnife® radiotherapy treatment field.

Details

Original languageEnglish
Pages (from-to)N419–N425
JournalPhysics in Medicine and Biology
Volume60
Issue number22
Publication statusPublished - 29 Oct 2015