Reading signals on the nucleosome with a new nomenclature for modified histones

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Abstract

The tails of the four core histones are exposed on the nucleosome surface, where they are subject to a variety of enzyme-catalyzed, post-translational modifications. Modifications, singly or in combination, provide a source of information that can be used for signal transduction during ongoing processes, such as transcription, or as heritable epigenetic marks. A nomenclature is presented that allows patterns of histone modification to be clearly and unambiguously specified and that should facilitate discussion of their functional roles.
Original languageEnglish
Pages (from-to)110-112
Number of pages3
JournalNature Structural and Molecular Biology
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Jan 2005

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