Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

Helen M Marriott; Laura E Jackson; Thomas S Wilkinson; A John Simpson; Tim J Mitchell; David J Buttle; Simon S Cross; Paul G Ince; Paul G Hellewell; Moira K B Whyte; David H Dockrell

doi:10.1164/rccm.200707-990OC

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

Helen M Marriott, Laura E Jackson, Thomas S Wilkinson, A John Simpson, Tim J Mitchell, David J Buttle, Simon S Cross, Paul G Ince, Paul G Hellewell, Moira K B Whyte, David H Dockrell

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

The role of NADPH oxidase activation in pneumonia is complex because reactive oxygen species contribute to both microbial killing and regulation of the acute pulmonary infiltrate. The relative importance of each role remains poorly defined in community-acquired pneumonia.

Original language	English
Pages (from-to)	887-95
Number of pages	9
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	177
Issue number	8
DOIs	https://doi.org/10.1164/rccm.200707-990OC
Publication status	Published - 15 Apr 2008

Keywords

Animals
Disease Models, Animal
Female
Inflammation
Membrane Glycoproteins
Mice
Mice, Knockout
NADPH Oxidase
Neutrophil Infiltration
Neutrophils
Pneumonia, Pneumococcal
Reactive Oxygen Species

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10.1164/rccm.200707-990OC

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Marriott, H. M., Jackson, L. E., Wilkinson, T. S., Simpson, A. J., Mitchell, T. J., Buttle, D. J., Cross, S. S., Ince, P. G., Hellewell, P. G., Whyte, M. K. B., & Dockrell, D. H. (2008). Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia. American Journal of Respiratory and Critical Care Medicine, 177(8), 887-95. https://doi.org/10.1164/rccm.200707-990OC

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title = "Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia",

abstract = "The role of NADPH oxidase activation in pneumonia is complex because reactive oxygen species contribute to both microbial killing and regulation of the acute pulmonary infiltrate. The relative importance of each role remains poorly defined in community-acquired pneumonia.",

keywords = "Animals, Disease Models, Animal, Female, Inflammation, Membrane Glycoproteins, Mice, Mice, Knockout, NADPH Oxidase, Neutrophil Infiltration, Neutrophils, Pneumonia, Pneumococcal, Reactive Oxygen Species",

author = "Marriott, {Helen M} and Jackson, {Laura E} and Wilkinson, {Thomas S} and Simpson, {A John} and Mitchell, {Tim J} and Buttle, {David J} and Cross, {Simon S} and Ince, {Paul G} and Hellewell, {Paul G} and Whyte, {Moira K B} and Dockrell, {David H}",

year = "2008",

month = apr,

day = "15",

doi = "10.1164/rccm.200707-990OC",

language = "English",

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journal = "American Journal of Respiratory and Critical Care Medicine",

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Marriott, HM, Jackson, LE, Wilkinson, TS, Simpson, AJ, Mitchell, TJ, Buttle, DJ, Cross, SS, Ince, PG, Hellewell, PG, Whyte, MKB & Dockrell, DH 2008, 'Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia', American Journal of Respiratory and Critical Care Medicine, vol. 177, no. 8, pp. 887-95. https://doi.org/10.1164/rccm.200707-990OC

TY - JOUR

T1 - Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

AU - Marriott, Helen M

AU - Jackson, Laura E

AU - Wilkinson, Thomas S

AU - Simpson, A John

AU - Mitchell, Tim J

AU - Buttle, David J

AU - Cross, Simon S

AU - Ince, Paul G

AU - Hellewell, Paul G

AU - Whyte, Moira K B

AU - Dockrell, David H

PY - 2008/4/15

Y1 - 2008/4/15

N2 - The role of NADPH oxidase activation in pneumonia is complex because reactive oxygen species contribute to both microbial killing and regulation of the acute pulmonary infiltrate. The relative importance of each role remains poorly defined in community-acquired pneumonia.

AB - The role of NADPH oxidase activation in pneumonia is complex because reactive oxygen species contribute to both microbial killing and regulation of the acute pulmonary infiltrate. The relative importance of each role remains poorly defined in community-acquired pneumonia.

KW - Animals

KW - Disease Models, Animal

KW - Female

KW - Inflammation

KW - Membrane Glycoproteins

KW - Mice

KW - Mice, Knockout

KW - NADPH Oxidase

KW - Neutrophil Infiltration

KW - Neutrophils

KW - Pneumonia, Pneumococcal

KW - Reactive Oxygen Species

U2 - 10.1164/rccm.200707-990OC

DO - 10.1164/rccm.200707-990OC

M3 - Article

C2 - 18202350

SN - 1073-449X

VL - 177

SP - 887

EP - 895

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 8

ER -

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

Abstract

Keywords

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