RATIONAL CENTRE SELECTION FOR RCTs WITH A PARALLEL ECONOMIC EVALUATION-THE NEXT STEP TOWARDS INCREASED GENERALISABILITY?

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@article{f255239e25db420096cac1c3d1702f1e,
title = "RATIONAL CENTRE SELECTION FOR RCTs WITH A PARALLEL ECONOMIC EVALUATION-THE NEXT STEP TOWARDS INCREASED GENERALISABILITY?",
abstract = "The paper discusses the impact of centre selection on the generalisability of randomised controlled trial (RCT)-based economic evaluations and suggests a future research agenda. The first section briefly reviews the current methods for addressing generalisability. We argue that these methods make no verifiable assumptions about how representative the recruiting centres are to the population of centres in the jurisdiction. The second section uses data from a multicentre RCT to illustrate that cost-effectiveness estimates can be influenced by the sample of recruiting centres. Finally, we propose two concepts that may advance generalisability research. First, we distinguish between the 'research space' and the 'policy space' and argue that policy makers are interested in the latter, while current methods describe the former. Second, we propose a centre-specific generalisability index used at RCT design stage to address generalisability. We conclude that future research should focus on generalisability at RCT design stage rather than on post hoc analyses. Copyright {\textcopyright} 2014 John Wiley & Sons, Ltd.",
author = "Adrian Gheorghe and Tracy Roberts and Pinkney, {Thomas D} and Morton, {Dion G} and Melanie Calvert",
note = "Copyright {\textcopyright} 2014 John Wiley & Sons, Ltd.",
year = "2014",
month = feb,
day = "13",
doi = "10.1002/hec.3039",
language = "English",
journal = "Health Economics",
issn = "1057-9230",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - RATIONAL CENTRE SELECTION FOR RCTs WITH A PARALLEL ECONOMIC EVALUATION-THE NEXT STEP TOWARDS INCREASED GENERALISABILITY?

AU - Gheorghe, Adrian

AU - Roberts, Tracy

AU - Pinkney, Thomas D

AU - Morton, Dion G

AU - Calvert, Melanie

N1 - Copyright © 2014 John Wiley & Sons, Ltd.

PY - 2014/2/13

Y1 - 2014/2/13

N2 - The paper discusses the impact of centre selection on the generalisability of randomised controlled trial (RCT)-based economic evaluations and suggests a future research agenda. The first section briefly reviews the current methods for addressing generalisability. We argue that these methods make no verifiable assumptions about how representative the recruiting centres are to the population of centres in the jurisdiction. The second section uses data from a multicentre RCT to illustrate that cost-effectiveness estimates can be influenced by the sample of recruiting centres. Finally, we propose two concepts that may advance generalisability research. First, we distinguish between the 'research space' and the 'policy space' and argue that policy makers are interested in the latter, while current methods describe the former. Second, we propose a centre-specific generalisability index used at RCT design stage to address generalisability. We conclude that future research should focus on generalisability at RCT design stage rather than on post hoc analyses. Copyright © 2014 John Wiley & Sons, Ltd.

AB - The paper discusses the impact of centre selection on the generalisability of randomised controlled trial (RCT)-based economic evaluations and suggests a future research agenda. The first section briefly reviews the current methods for addressing generalisability. We argue that these methods make no verifiable assumptions about how representative the recruiting centres are to the population of centres in the jurisdiction. The second section uses data from a multicentre RCT to illustrate that cost-effectiveness estimates can be influenced by the sample of recruiting centres. Finally, we propose two concepts that may advance generalisability research. First, we distinguish between the 'research space' and the 'policy space' and argue that policy makers are interested in the latter, while current methods describe the former. Second, we propose a centre-specific generalisability index used at RCT design stage to address generalisability. We conclude that future research should focus on generalisability at RCT design stage rather than on post hoc analyses. Copyright © 2014 John Wiley & Sons, Ltd.

U2 - 10.1002/hec.3039

DO - 10.1002/hec.3039

M3 - Article

C2 - 24523070

JO - Health Economics

JF - Health Economics

SN - 1057-9230

ER -